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HST2 histone deacetylase HST2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856092, updated on 4-Dec-2018

Summary

Gene symbol
HST2
Gene description
histone deacetylase HST2
Primary source
SGD:S000005936
Locus tag
YPL015C
Gene type
protein coding
RNA name
histone deacetylase HST2
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See HST2 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (525810..526883, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Ctf19p Neighboring gene Irc15p Neighboring gene Swi1p Neighboring gene Cip1p Neighboring gene mitochondrial 37S ribosomal protein MRPS16

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the HST2 gene: The HST2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 
NAD-dependent histone deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
chromatin silencing at rDNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
chronological cell aging IGI
Inferred from Genetic Interaction
more info
PubMed 
chronological cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of chromatin silencing at telomere IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mitotic recombination IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mitotic recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone deacetylase HST2
NP_015310.1
  • Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    525810..526883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183829.1NP_015310.1  TPA: histone deacetylase HST2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015310.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53686
    Conserved Domains (1) summary
    cd01408
    Location:26277
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
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