SWI1 Swi1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SWI1
Official Full Name: Swi1p
Primary source: SGD:S000005937
Locus tag: YPL016W
See related: AllianceGenome:SGD:S000005937; FungiDB:YPL016W; VEuPathDB:YPL016W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADR6; GAM3; LPA1
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including cellular response to amino acid starvation; positive regulation of mating type switching; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of SWI/SNF complex. Orthologous to human ARID5B (AT-rich interaction domain 5B). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See SWI1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (521014..524958)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction.
Title: Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction.
Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.
Title: Defining Key Residues of the Swi1 Prion Domain in Prion Formation and Maintenance.
Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses.
Title: Elucidating the regulatory mechanism of Swi1 prion in global transcription and stress responses.
Structure of the yeast Swi/Snf complex in a nucleosome free state.
Title: Structure of the yeast Swi/Snf complex in a nucleosome free state.
NH2-terminal region of approximately 30 amino acids of Swi1 contains all the necessary information for in vivo prion formation, maintenance, and transmission
Title: Analysis of Small Critical Regions of Swi1 Conferring Prion Formation, Maintenance, and Transmission.
SWI1 overexpression is a Pin+ factor independent of Rnq1; [SWI+] can facilitate [PSI+] conversion but weaken the Pin+ function of [PIN+]
Title: Investigating the interactions of yeast prions: [SWI+], [PSI+], and [PIN+].
Results provide proof of "protein-only" transmission of [SWI(+)] and demonstrate that the widely distributed "dispensable" glutamine/asparagine-rich regions/motifs might have important and divergent biological functions.
Title: Distinct subregions of Swi1 manifest striking differences in prion transmission and SWI/SNF function.
integrity of S. cerevisiae Swi/Snf complex is required for invasive and filamentous growth promoted by overexpressing CaSwi1
Title: Functional analysis of ScSwi1 and CaSwi1 in invasive and pseudohyphal growth of Saccharomyces cerevisiae.
Results suggest that the SWI/SNF complex is directly involved in nucleosome removal at HO, and that the histone chaperone Asf1 assists in this during the course of gene regulation.
Title: SWI/SNF and Asf1p cooperate to displace histones during induction of the saccharomyces cerevisiae HO promoter.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of SWI/SNF complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	NAS Non-traceable Author Statement more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Swi1p

NP_015309.1

Subunit of the SWI/SNF chromatin remodeling complex; regulates transcription by remodeling chromatin; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; self-assembles to form [SWI+] prion and to alter expression pattern; human homolog ARID1A is a candidate tumor suppressor gene in breast cancer

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

521014..524958

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183830.2 → NP_015309.1 Swi1p

See identical proteins and their annotated locations for NP_015309.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3Z6, P09547

UniProtKB/TrEMBL

B3LL46

Conserved Domains (1) summary

cd16871
Location:407 → 490

ARID_Swi1p-like; ARID/BRIGHT DNA binding domain of yeast SWI/SNF chromatin-remodeling complex subunit Swi1p and similar proteins