MET12 methylenetetrahydrofolate reductase (NAD(P)H) MET12 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: MET12
Gene description: methylenetetrahydrofolate reductase (NAD(P)H) MET12
Primary source: SGD:S000005944
Locus tag: YPL023C
See related: AllianceGenome:SGD:S000005944
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables methylenetetrahydrofolate reductase (NAD(P)H) activity. Predicted to be involved in methionine biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cardiovascular system disease (multiple); hematologic cancer (multiple); and kidney failure (multiple). Orthologous to human MTHFR (methylenetetrahydrofolate reductase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables FAD binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IDA Inferred from Direct Assay more info	PubMed
enables methylenetetrahydrofolate reductase (NAD(P)H) activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase NADH activity	IEA Inferred from Electronic Annotation more info
enables methylenetetrahydrofolate reductase NADPH activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in methionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in methionine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

NP_015302.1

Protein with MTHFR activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of methylenetetrahydrofolate reductase (MTHFR)

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The following sections contain reference sequences that belong to a specific genome build. Explain