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TRM44 tRNA (uracil) methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856077, updated on 7-Jun-2026
Official Symbol
TRM44
Official Full Name
tRNA (uracil) methyltransferase
Primary source
SGD:S000005951
Locus tag
YPL030W
See related
AllianceGenome:SGD:S000005951; FungiDB:YPL030W; VEuPathDB:YPL030W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA (uridine) methyltransferase activity. Involved in tRNA nucleoside ribose methylation. Located in cytoplasm. Orthologous to human TRMT44 (tRNA methyltransferase 44 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TRM44 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (493543..495246)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Svl3p Neighboring gene cyclin-dependent serine/threonine-protein kinase PHO85 Neighboring gene ATP-dependent RNA helicase SUV3 Neighboring gene acetyl-CoA C-acetyltransferase

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Chan CT, et al. PLoS Genet, 2010 Dec 16. PMID 21187895, Free PMC Article
  2. Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. Kotelawala L, et al. RNA, 2008 Jan. PMID 18025252, Free PMC Article
  3. 2'-O-ribose methylation of transfer RNA promotes recovery from oxidative stress in Saccharomyces cerevisiae. Endres L, et al. PLoS One, 2020. PMID 32053677, Free PMC Article
  4. The yeast rapid tRNA decay pathway competes with elongation factor 1A for substrate tRNAs and acts on tRNAs lacking one or more of several modifications. Dewe JM, et al. RNA, 2012 Oct. PMID 22895820, Free PMC Article
  5. Degradation of several hypomodified mature tRNA species in Saccharomyces cerevisiae is mediated by Met22 and the 5'-3' exonucleases Rat1 and Xrn1. Chernyakov I, et al. Genes Dev, 2008 May 15. PMID 18443146, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA (uridine) methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA (uridine) methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA (uridine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA(Ser) (uridine(44)-2'-O-ribose)-methyltransferase activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation TAS
Traceable Author Statement
more info
  
involved_in tRNA nucleoside ribose methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
Preferred Names
tRNA (uracil) methyltransferase
NP_015295.1
  • tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    493543..495246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183844.1 → NP_015295.1  tRNA (uracil) methyltransferase

    See identical proteins and their annotated locations for NP_015295.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Y3, Q02648, Q03090, Q2XN15
    UniProtKB/TrEMBL
    A6ZWL7, C7GU22, C8ZIZ9, G2WPE8, N1NVI4
    Conserved Domains (1) summary
    pfam07757
    Location:257 → 370
    AdoMet_MTase; Predicted AdoMet-dependent methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02648.1

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