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LGE1 Lge1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856052, updated on 18-Sep-2024

Summary

Official Symbol
LGE1
Official Full Name
Lge1p
Primary source
SGD:S000005976
Locus tag
YPL055C
See related
AllianceGenome:SGD:S000005976; FungiDB:YPL055C; VEuPathDB:YPL055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in histone methylation; premeiotic DNA replication; and protein ubiquitination. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See LGE1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (453992..454990, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 Neighboring gene Lcl1p Neighboring gene Lee1p Neighboring gene putative mannosyltransferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
Lge1p
NP_015270.1
  • Protein that facilitates co-transcriptional histone H2B ubiquitination; scaffold protein that promotes oligomerization of E3 ligase Bre1p; contains an intrinsically disordered region that phase separates, to form a core encapsulated by Bre1p that recruits Ub-conjugating enzyme Rad6p, elevating catalytic activity along gene bodies; null mutant forms abnormally large cells, and homozygous null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    453992..454990 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183869.1NP_015270.1  TPA: Lge1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V9, Q02796, Q6Q5I8
    UniProtKB/TrEMBL
    G2WPC3, N1NX97
    Conserved Domains (1) summary
    pfam11488
    Location:251329
    Lge1; Transcriptional regulatory protein LGE1