SUR1 mannosylinositol phosphorylceramide synthase catalytic subunit SUR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: SUR1
Official Full Name: mannosylinositol phosphorylceramide synthase catalytic subunit SUR1
Primary source: SGD:S000005978
Locus tag: YPL057C
See related: AllianceGenome:SGD:S000005978; FungiDB:YPL057C; VEuPathDB:YPL057C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BCL21; CSG1; LPE15
Summary: Enables inositol phosphorylceramide mannosyltransferase activity. Involved in glycosphingolipid biosynthetic process and mannosyl-inositol phosphorylceramide metabolic process. Located in fungal-type vacuole membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Go to the top of the page Help

See SUR1 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (451909..453057, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
Title: Pleiotropic roles of N-glycans for enzyme activities and stabilities of MIPC synthases, Csh1 and Sur1/Csg1, in Saccharomyces cerevisiae.
Csg2 has several regulatory functions for Csg1 and Csh1, including stability, transport, and gene expression
Title: Regulation of the transport and protein levels of the inositol phosphorylceramide mannosyltransferases Csg1 and Csh1 by the Ca2+-binding protein Csg2.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables inositol phosphorylceramide mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables inositol phosphorylceramide mannosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycosphingolipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycosphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mannosyl diphosphorylinositol ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in mannosyl diphosphorylinositol ceramide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in mannosyl-inositol phosphorylceramide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in mannosyl-inositol phosphorylceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	NAS Non-traceable Author Statement more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
part_of mannosyltransferase complex	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: mannosylinositol phosphorylceramide synthase catalytic subunit SUR1

NP_015268.1

EC 2.4.1.370

Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

451909..453057 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183871.1 → NP_015268.1 mannosylinositol phosphorylceramide synthase catalytic subunit SUR1

See identical proteins and their annotated locations for NP_015268.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3V7, P33300

UniProtKB/TrEMBL

A6ZWJ1, C7GTZ9, C8ZIX3, N1NW47

Conserved Domains (1) summary

COG3774
Location:1 → 322

OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]