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CWC27 putative peptidylprolyl isomerase CWC27 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856041, updated on 5-Jul-2025
Official Symbol
CWC27
Official Full Name
putative peptidylprolyl isomerase CWC27
Primary source
SGD:S000005985
Locus tag
YPL064C
See related
AllianceGenome:SGD:S000005985; FungiDB:YPL064C; VEuPathDB:YPL064C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Part of U2-type spliceosomal complex. Orthologous to human CWC27 (CWC27 spliceosome associated cyclophilin). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See CWC27 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (428711..429616, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rgl1p Neighboring gene ESCRT-I subunit protein VPS28 Neighboring gene protein translocase subunit TIM50 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The DExD/H-box ATPase Prp2p destabilizes and proofreads the catalytic RNA core of the spliceosome. Wlodaver AM, et al. RNA, 2014 Mar. PMID 24442613, Free PMC Article
  2. Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. van Nues RW, et al. Genetics, 2001 Apr. PMID 11290703, Free PMC Article
  3. Structure of a yeast activated spliceosome at 3.5 Å resolution. Yan C, et al. Science, 2016 Aug 26. PMID 27445306
  4. Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase. Cordin O, et al. Nucleic Acids Res, 2014 Dec 16. PMID 25428373, Free PMC Article
  5. Release of SF3 from the intron branchpoint activates the first step of pre-mRNA splicing. Lardelli RM, et al. RNA, 2010 Mar. PMID 20089683, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U2-type spliceosomal complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
putative peptidylprolyl isomerase CWC27
NP_015261.1
  • Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p; protein abundance increases in response to DNA replication stress

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    428711..429616 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183878.1 → NP_015261.1  TPA: putative peptidylprolyl isomerase CWC27

    See identical proteins and their annotated locations for NP_015261.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V1, Q02770
    UniProtKB/TrEMBL
    G2WPB6, N1P1Q2
    Conserved Domains (1) summary
    cl00197
    Location:6 → 167
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02770.1

Gene LinkOut

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