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VPS28 ESCRT-I subunit protein VPS28 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856040, updated on 3-May-2025
Official Symbol
VPS28
Official Full Name
ESCRT-I subunit protein VPS28
Primary source
SGD:S000005986
Locus tag
YPL065W
See related
AllianceGenome:SGD:S000005986; FungiDB:YPL065W; VEuPathDB:YPL065W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
VPL13; VPT28
Summary
Involved in ATP export; protein targeting to membrane; and protein targeting to vacuole. Located in endosome. Part of ESCRT I complex. Orthologous to human VPS28 (VPS28 subunit of ESCRT-I). [provided by Alliance of Genome Resources, May 2025]
Orthologs
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See VPS28 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (427927..428655)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Htc1p Neighboring gene Rgl1p Neighboring gene putative peptidylprolyl isomerase CWC27 Neighboring gene protein translocase subunit TIM50

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant. Rieder SE, et al. Mol Biol Cell, 1996 Jun. PMID 8817003, Free PMC Article
  2. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Babst M, et al. Traffic, 2000 Mar. PMID 11208108
  3. Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy. Boura E, et al. Proc Natl Acad Sci U S A, 2011 Jun 7. PMID 21596998, Free PMC Article
  4. The crystal structure of the C-terminal domain of Vps28 reveals a conserved surface required for Vps20 recruitment. Pineda-Molina E, et al. Traffic, 2006 Aug. PMID 16749904
  5. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Katzmann DJ, et al. Cell, 2001 Jul 27. PMID 11511343

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the conformations provide reference points for the structural pathway by which ESCRT-I induces membrane buds.
    Title: Solution structure of the ESCRT-I complex by small-angle X-ray scattering, EPR, and FRET spectroscopy.
  2. show that Rim8 coimmunoprecipitates with ESCRT-I subunits Vps23 and Vps28, supporting the idea that binding of Rim8 to Vps23 mediates the association of Rim8 with the ESCRT-I complex.
    Title: Recruitment of the ESCRT machinery to a putative seven-transmembrane-domain receptor is mediated by an arrestin-related protein.
  3. The yeast ESCRT-I complex contains the Vps23, Vps28, and Vps37 proteins, and its assembly is directed by the C-terminal steadiness box of Vps23, the N-terminal half of Vps28, and the C-terminal half of Vps37.
    Title: Structural and functional organization of the ESCRT-I trafficking complex.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP export IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endosome transport via multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within establishment of protein localization to vacuole IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vacuolar transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ESCRT I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ESCRT I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ESCRT I complex IEA
Inferred from Electronic Annotation
more info
  
part_of ESCRT I complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
ESCRT-I subunit protein VPS28
NP_015260.1
  • Component of the ESCRT-I complex; complex is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p; other members include Stp22p, Srn2p, Vps28p, and Mvb12p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    427927..428655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183879.1 → NP_015260.1  TPA: ESCRT-I subunit protein VPS28 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015260.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V0, E9P8X2, P87328, Q02767
    UniProtKB/TrEMBL
    C7GTZ2, G2WPB5, N1NVH7
    Conserved Domains (1) summary
    pfam03997
    Location:40 → 241
    VPS28; VPS28 protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02767.1

Gene LinkOut

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