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RPL21B 60S ribosomal protein eL21 RPL21B [ Saccharomyces cerevisiae S288C ]

Gene ID: 856026, updated on 3-Jun-2026
Official Symbol
RPL21B
Official Full Name
60S ribosomal protein eL21 RPL21B
Primary source
SGD:S000006000
Locus tag
YPL079W
See related
AllianceGenome:SGD:S000006000; FungiDB:YPL079W; VEuPathDB:YPL079W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Predicted to act upstream of or within translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in hypotrichosis 12. Orthologous to human RPL21 (ribosomal protein L21). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
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See RPL21B in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (406636..407539)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein uS4 RPS9A Neighboring gene uncharacterized protein Neighboring gene F1F0 ATP synthase subunit 4 Neighboring gene uncharacterized protein

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Innate immunity to yeast prions: Btn2p and Cur1p curing of the [URE3] prion is prevented by 60S ribosomal protein deficiency or ubiquitin/proteasome system overactivity. Bezsonov EE, et al. Genetics, 2021 Apr 15. PMID 33857305, Free PMC Article
  2. Genome-wide association across Saccharomyces cerevisiae strains reveals substantial variation in underlying gene requirements for toxin tolerance. Sardi M, et al. PLoS Genet, 2018 Feb. PMID 29474395, Free PMC Article
  3. Sensitivity of yeast to lithium chloride connects the activity of YTA6 and YPR096C to translation of structured mRNAs. Hajikarimlou M, et al. PLoS One, 2020. PMID 32639961, Free PMC Article
  4. Plant-derived antifungal agent poacic acid targets β-1,3-glucan. Piotrowski JS, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775513, Free PMC Article
  5. Cell size and growth rate are major determinants of replicative lifespan. Yang J, et al. Cell Cycle, 2011 Jan 1. PMID 21248481, Free PMC Article

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
60S ribosomal protein eL21 RPL21B
NP_015246.1
  • Ribosomal 60S subunit protein L21B; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21B has a paralog, RPL21A, that arose from the whole genome duplication

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    406636..407539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183893.1 → NP_015246.1  60S ribosomal protein eL21 RPL21B

    See identical proteins and their annotated locations for NP_015246.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3T7, Q12672
    UniProtKB/TrEMBL
    A6ZWH1, B3LKZ1, C8ZIV1, G2WPA2, N1NVX6
    Conserved Domains (1) summary
    PTZ00189
    Location:1 → 157
    PTZ00189; 60S ribosomal protein L21; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12672.1

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