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GLR1 glutathione-disulfide reductase GLR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856014, updated on 4-Jan-2025

Summary

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Official Symbol
GLR1
Official Full Name
glutathione-disulfide reductase GLR1
Primary source
SGD:S000006012
Locus tag
YPL091W
See related
AllianceGenome:SGD:S000006012; FungiDB:YPL091W; VEuPathDB:YPL091W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPG17
Summary
Enables glutathione-disulfide reductase (NADPH) activity. Involved in several processes, including cell redox homeostasis; glutathione metabolic process; and protein glutathionylation. Located in cytosol; nucleus; and peroxisome. Used to study limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See GLR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (375502..376953)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative GTPase NOG1 Neighboring gene Ssu1p Neighboring gene ribosomal 40S subunit protein S6A Neighboring gene Rlm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. In vitro effects of imatinib on glucose-6-phosphate dehydrogenase and glutathione reductase. Tandogan B, et al. Folia Biol (Praha), 2011. PMID 21631962
  2. The redox interconversion mechanism of Saccharomyces cerevisiae glutathione reductase. Pinto MC, et al. Eur J Biochem, 1985 Sep 2. PMID 3896786
  3. Reversible inactivation of Saccharomyces cerevisiae glutathione reductase under reducing conditions. Pinto MC, et al. Arch Biochem Biophys, 1984 Jan. PMID 6364985
  4. Recognition site of yeast glutathione reductase for 2'-phosphate of NADP+. Tsai CS. Biochem Biophys Res Commun, 1984 Oct 30. PMID 6388577
  5. Simultaneous inactivation of the catalytic activities of yeast glutathione reductase by N-alkylmaleimides. Dubler RE, et al. Biochim Biophys Acta, 1981 May 14. PMID 7018585

See all (140) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We show that the loss of mitochondrial Glr1 specifically accounts for oxidant sensitivity of a glr1 mutant. Loss of mitochondrial Glr1 does not influence iron-sulphur cluster maturation and we have used targeted roGFP2 fluorescent probes to show that oxidant sensitivity is linked to an altered redox environment
    Title: Yeast mitochondrial glutathione is an essential antioxidant with mitochondrial thioredoxin providing a back-up system.
  2. The second AUG appears to be responsible for most of the cellular Glr1.
    Title: Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach.
  3. yeast GR is inactivated by a reductive mechanism mediated by NADPH and Fe(II)
    Title: Reductive inactivation of yeast glutathione reductase by Fe(II) and NADPH.
  4. Yeast glutathione (GSH) reductase Glr1 is a dimeric flavo-oxidoreductase involved in cytoplasmic and mitochondrial redox, regulatory systems
    Title: Crystal structure of glutathione reductase Glr1 from the yeast Saccharomyces cerevisiae.
  5. GLR1 plays an essential role in the homeodynamics of glutathion and the regulation of H(2)S production
    Title: GLR1 plays an essential role in the homeodynamics of glutathione and the regulation of H2S production during respiratory oscillation of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in cell redox homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glutathionylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
glutathione-disulfide reductase GLR1
NP_015234.1
  • Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    375502..376953
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183905.1 → NP_015234.1  TPA: glutathione-disulfide reductase GLR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015234.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3S6, P41921
    UniProtKB/TrEMBL
    C8ZIT9, G2WP90, N1NX64
    Conserved Domains (1) summary
    TIGR01421
    Location:22 → 483
    gluta_reduc_1; glutathione-disulfide reductase, animal/bacterial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P41921.2

Gene LinkOut

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