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ERI1 Eri1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856008, updated on 3-Jun-2026
Official Symbol
ERI1
Official Full Name
Eri1p
Primary source
SGD:S000028423
Locus tag
YPL096C-A
See related
AllianceGenome:SGD:S000028423; FungiDB:YPL096C-A; VEuPathDB:YPL096C-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RIN1
Summary
Enables GTPase inhibitor activity. Involved in GPI anchor biosynthetic process and Ras protein signal transduction. Located in endoplasmic reticulum membrane. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ERI1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (366529..366735, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Mgr2p Neighboring gene tyrosine--tRNA ligase MSY1 Neighboring gene peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase Neighboring gene medium-chain fatty acid ethyl ester synthase/esterase

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A novel Ras inhibitor, Eri1, engages yeast Ras at the endoplasmic reticulum. Sobering AK, et al. Mol Cell Biol, 2003 Jul. PMID 12832483, Free PMC Article
  2. Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Newman HA, et al. Eukaryot Cell, 2005 Nov. PMID 16278447, Free PMC Article
  3. Yeast Ras regulates the complex that catalyzes the first step in GPI-anchor biosynthesis at the ER. Sobering AK, et al. Cell, 2004 May 28. PMID 15163411
  4. Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum. Kajiwara K, et al. Mol Biol Cell, 2008 May. PMID 18287539, Free PMC Article
  5. Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Kastenmayer JP, et al. Genome Res, 2006 Mar. PMID 16510898, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables GTPase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GPI anchor biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
Eri1p
NP_690846.1
  • Endoplasmic reticulum membrane protein that binds and inhibits Ras2p; binds to and inhibits GTP-bound Ras2p at the endoplasmic reticulum (ER); component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    366529..366735 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184515.1 → NP_690846.1  Eri1p

    See identical proteins and their annotated locations for NP_690846.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3S0, P62651
    UniProtKB/TrEMBL
    A6ZWF4, B3LKX6, C7GJ51, C8ZIT3, G2WP84
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62651.1

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