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IDI1 isopentenyl-diphosphate delta-isomerase IDI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855986, updated on 14-Apr-2023

Summary

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Gene symbol
IDI1
Gene description
isopentenyl-diphosphate delta-isomerase IDI1
Primary source
SGD:S000006038
Locus tag
YPL117C
See related
AllianceGenome:SGD:S000006038
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BOT2; LPH10
Summary
Enables isopentenyl-diphosphate delta-isomerase activity. Involved in farnesyl diphosphate biosynthetic process. Located in cytosol and nucleus. Used to study cancer. Orthologous to several human genes including IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IDI1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (327864..328730, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative DEAD-box ATP-dependent RNA helicase DBP1 Neighboring gene mitochondrial 37S ribosomal protein MRP51 Neighboring gene histone deacetylase Neighboring gene GTPase-activating protein BEM3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhancement of the catalytic activity of Isopentenyl diphosphate isomerase (IDI) from Saccharomyces cerevisiae through random and site-directed mutagenesis. Chen H, et al. Microb Cell Fact, 2018 Apr 30. PMID 29712558, Free PMC Article
  2. Isopentenyl diphosphate isomerase catalyzed reactions in D2O: product release limits the rate of this sluggish enzyme-catalyzed reaction. Jonnalagadda V, et al. J Am Chem Soc, 2012 Apr 18. PMID 22471428, Free PMC Article
  3. Expression of an exogenous isopentenyl diphosphate isomerase gene enhances isoprenoid biosynthesis in Escherichia coli. Kajiwara S, et al. Biochem J, 1997 Jun 1. PMID 9182699, Free PMC Article
  4. Enzymatic synthesis of isotopically labeled isoprenoid diphosphates. Christensen DJ, et al. Bioorg Med Chem, 1994 Jul. PMID 7858969
  5. Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. Reardon JE, et al. Biochemistry, 1986 Sep 23. PMID 3022798

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isopentenyl-diphosphate delta-isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in dimethylallyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
isopentenyl-diphosphate delta-isomerase IDI1
NP_015208.1
  • Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    327864..328730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183931.1 → NP_015208.1  TPA: isopentenyl-diphosphate delta-isomerase IDI1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015208.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Q1, P15496
    UniProtKB/TrEMBL
    A0A0L8VGH5, A0A6A5Q2P4, A0A6C1E1Q4, A6ZWD5, B5VT49, C7GJ70, C8ZIR3, G2WP65, H0GPJ9, N1NW25
    Conserved Domains (1) summary
    COG1443
    Location:69 → 281
    Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15496.2

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