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IDI1 isopentenyl-diphosphate delta-isomerase IDI1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855986, updated on 3-Jun-2026
Official Symbol
IDI1
Official Full Name
isopentenyl-diphosphate delta-isomerase IDI1
Primary source
SGD:S000006038
Locus tag
YPL117C
See related
AllianceGenome:SGD:S000006038; FungiDB:YPL117C; VEuPathDB:YPL117C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BOT2; LPH10
Summary
Enables isopentenyl-diphosphate delta-isomerase activity. Involved in ergosterol biosynthetic process and farnesyl diphosphate biosynthetic process. Located in cytosol and nucleus. Used to study cancer. Orthologous to human IDI1 (isopentenyl-diphosphate delta isomerase 1) and IDI2 (isopentenyl-diphosphate delta isomerase 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See IDI1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (327864..328730, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative DEAD-box ATP-dependent RNA helicase DBP1 Neighboring gene mitochondrial 37S ribosomal protein bS1m MRP51 Neighboring gene histone deacetylase Neighboring gene GTPase-activating protein BEM3

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isopentenyl-diphosphate isomerase: irreversible inhibition by 3-methyl-3,4-epoxybutyl diphosphate. Lu XJ, et al. Biochemistry, 1992 Oct 20. PMID 1390779
  2. Disruption and mapping of IDI1, the gene for isopentenyl diphosphate isomerase in Saccharomyces cerevisiae. Mayer MP, et al. Yeast, 1992 Sep. PMID 1441751
  3. Isopentenyldiphosphate:dimethylallyldiphosphate isomerase: construction of a high-level heterologous expression system for the gene from Saccharomyces cerevisiae and identification of an active-site nucleophile. Street IP, et al. Biochemistry, 1990 Aug 14. PMID 2223785
  4. Isopentenyl diphosphate:dimethylallyl diphosphate isomerase. An improved purification of the enzyme and isolation of the gene from Saccharomyces cerevisiae. Anderson MS, et al. J Biol Chem, 1989 Nov 15. PMID 2681212
  5. Mechanism of action of isopentenyl pyrophosphate isomerase: evidence for a carbonium ion intermediate. Reardon JE, et al. Biochemistry, 1986 Sep 23. PMID 3022798

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isopentenyl-diphosphate delta-isomerase activity EXP
Inferred from Experiment
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isopentenyl-diphosphate delta-isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables isopentenyl-diphosphate delta-isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables isopentenyl-diphosphate delta-isomerase activity RCA
inferred from Reviewed Computational Analysis
more info
  
Process Evidence Code Pubs
involved_in dimethylallyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in isopentenyl diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
involved_in trans, trans-farnesyl diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in trans, trans-farnesyl diphosphate biosynthetic process RCA
inferred from Reviewed Computational Analysis
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
  
located_in nucleus HDA PubMed 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
isopentenyl-diphosphate delta-isomerase IDI1
NP_015208.1
  • Isopentenyl diphosphate:dimethylallyl diphosphate isomerase; catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability; isopentenyl diphosphate:dimethylallyl diphosphate isomerase is also known as IPP isomerase

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    327864..328730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183931.1 → NP_015208.1  isopentenyl-diphosphate delta-isomerase IDI1

    See identical proteins and their annotated locations for NP_015208.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3Q1, P15496
    UniProtKB/TrEMBL
    A6ZWD5, B5VT49, C7GJ70, C8ZIR3, G2WP65, N1NW25
    Conserved Domains (1) summary
    COG1443
    Location:69 → 281
    Idi; Isopentenyldiphosphate isomerase [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15496.2

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