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VPS30 beclin 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855983, updated on 9-Sep-2018

Summary

Gene symbol
VPS30
Gene description
beclin 1
Primary source
SGD:S000006041
Locus tag
YPL120W
Gene type
protein coding
RNA name
beclin 1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APG6; ATG6; VPT30

Genomic context

See VPS30 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (322071..323744)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene TFIIH/NER complex subunit TFB2 Neighboring gene Mei5p Neighboring gene hypothetical protein Neighboring gene putative DEAD-box ATP-dependent RNA helicase DBP1

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the VPS30 gene: The VPS30 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy of peroxisome IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to nitrogen starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome to vacuole transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome to vacuole transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization by the Cvt pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IGI
Inferred from Genetic Interaction
more info
PubMed 
retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol HDA PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
fungal-type vacuole membrane HDA PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore assembly site membrane IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type I IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IDA
Inferred from Direct Assay
more info
PubMed 
vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
vacuole IEA
Inferred from Electronic Annotation
more info
 
vacuole-isolation membrane contact site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
beclin 1
NP_015205.1
  • Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    322071..323744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183934.1NP_015205.1  TPA: beclin 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015205.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q02948
    Conserved Domains (1) summary
    pfam04111
    Location:180535
    APG6; Autophagy protein Apg6
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