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HHO1 histone H1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855976, updated on 29-Jun-2024

Summary

Gene symbol
HHO1
Gene description
histone H1
Primary source
FungiDB:YPL127C
Locus tag
YPL127C
See related
SGD:S000006048; AllianceGenome:SGD:S000006048; VEuPathDB:YPL127C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables DNA binding activity. Involved in chromosome condensation; negative regulation of DNA recombination; and regulation of transcription, DNA-templated. Acts upstream of or within regulation of double-strand break repair. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including H1-0 (H1.0 linker histone). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See HHO1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (308828..309604, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene TATA-binding protein-associated factor TAF14 Neighboring gene Tbf1p Neighboring gene Nan1p Neighboring gene Kap120p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in chromosome condensation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of DNA recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sporulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
histone H1
NP_015198.1
  • Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    308828..309604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183941.1NP_015198.1  TPA: histone H1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015198.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P0, P53551, Q6Q5R6
    UniProtKB/TrEMBL
    A0A6A5Q624, A6ZWC5, B3LKU8, C7GJ81, G2WP54, N1P1I5
    Conserved Domains (1) summary
    pfam00538
    Location:44116
    Linker_histone; linker histone H1 and H5 family