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TAF14 TATA-binding protein-associated factor TAF14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855974, updated on 15-Mar-2026
Official Symbol
TAF14
Official Full Name
TATA-binding protein-associated factor TAF14
Primary source
SGD:S000006050
Locus tag
YPL129W
See related
AllianceGenome:SGD:S000006050; FungiDB:YPL129W; VEuPathDB:YPL129W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ANC1; SWP29; TAF30; TFG3
Summary
Enables DNA binding activity and RNA polymerase II general transcription initiation factor activity. Involved in chromatin remodeling and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of RNA polymerase II, holoenzyme; chromatin; and mediator complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); MLLT3 (MLLT3 super elongation complex subunit); and YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See TAF14 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (305298..306137)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein uL18 RPL5 Neighboring gene Spo19p Neighboring gene Tbf1p Neighboring gene histone H1

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. A meta-analysis reveals complex regulatory properties at Taf14-repressed genes. Nemet J, et al. BMC Genomics, 2017 Feb 16. PMID 28209126, Free PMC Article
  2. Solution structure of the Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae. Zhang W, et al. Biochem J, 2011 May 15. PMID 21355849
  3. The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene. Dahan O, et al. Nucleic Acids Res, 2004. PMID 15133121, Free PMC Article
  4. A nuclear protein with sequence similarity to proteins implicated in human acute leukemias is important for cellular morphogenesis and actin cytoskeletal function in Saccharomyces cerevisiae. Welch MD, et al. Mol Biol Cell, 1994 Jun. PMID 7949419, Free PMC Article
  5. Purification and characterization of yeast RNA polymerase II general initiation factor g. Henry NL, et al. J Biol Chem, 1992 Nov 15. PMID 1331085

See all (214) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Transcriptional regulator Taf14 binds DNA and is required for the function of transcription factor TFIID in the absence of histone H2A.Z.
    Title: Transcriptional regulator Taf14 binds DNA and is required for the function of transcription factor TFIID in the absence of histone H2A.Z.
  2. Taf2 mediates DNA binding of Taf14.
    Title: Taf2 mediates DNA binding of Taf14.
  3. Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.
    Title: Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.
  4. Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
    Title: Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
  5. Histone crotonylation and Taf14 participate in the repression of energy-demanding gene expression in S.cerevisiae.
    Title: Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.
  6. a novel role for Taf14 in repression and derepression of stress induced genes
    Title: A meta-analysis reveals complex regulatory properties at Taf14-repressed genes.
  7. the mechanism through which Taf14 suppresses taf2(ts) alleles, shedding light on how Taf2-Taf14 interaction contributes to TFIID complex organization and identifying a potential role for Taf14 in mediating TFIID-chromatin interactions.
    Title: The C Terminus of the RNA Polymerase II Transcription Factor IID (TFIID) Subunit Taf2 Mediates Stable Association of Subunit Taf14 into the Yeast TFIID Complex.
  8. the YEATS domain of Taf14, a member of key transcriptional and chromatin-modifying complexes in yeast, is a selective reader of histone H3 Lys9 acetylation (H3K9ac).
    Title: Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
  9. Taf14 is involved in transcriptional activation of Saccharomyces cerevisiae and the YEATS domain of Taf14 might play a negative role in cell growth.
    Title: Solution structure of the Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae.
  10. show here that the YEATS domain is not necessary for Taf14's association with transcription stimulatory activity and chromatin remodeling complexes.
    Title: The YEATS domain of Taf14 in Saccharomyces cerevisiae has a negative impact on cell growth.
Submit: New GeneRIF Correction See all GeneRIFs (12)
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of NuA3 histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3a histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of NuA3b histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin NAS
Non-traceable Author Statement
more info
 PubMed 
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIF complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
TATA-binding protein-associated factor TAF14
NP_015196.1
  • Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; serves as an additional DNA binding domain for the complex; contains a YEATS domain

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    305298..306137
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183943.1 → NP_015196.1  TATA-binding protein-associated factor TAF14

    See identical proteins and their annotated locations for NP_015196.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3N8, P35189, Q02460
    UniProtKB/TrEMBL
    A6ZWC3, B3LKU6, C8ZIQ1, G2WP52, N1NVV6
    Conserved Domains (1) summary
    COG5033
    Location:2 → 242
    TFG3; Transcription initiation factor IIF, auxiliary subunit [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35189.1

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