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RPL5 60S ribosomal protein uL18 RPL5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855972, updated on 23-Jul-2026
Official Symbol
RPL5
Official Full Name
60S ribosomal protein uL18 RPL5
Primary source
SGD:S000006052
Locus tag
YPL131W
See related
AllianceGenome:SGD:S000006052; FungiDB:YPL131W; VEuPathDB:YPL131W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPI14; RPL1
Summary
Enables 5S rRNA binding activity. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 6; T-cell acute lymphoblastic leukemia; and glioblastoma. Orthologous to human RPL5 (ribosomal protein L5). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See RPL5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (303121..304014)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene gluconeogenesis transcription factor RDS2 Neighboring gene Cox11p Neighboring gene Spo19p Neighboring gene TATA-binding protein-associated factor TAF14

Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The 5-S RNA binding protein from yeast (Saccharomyces cerevisiae) ribosomes. Evolution of the eukaryotic 5-S RNA binding protein. Nazar RN, et al. Eur J Biochem, 1979 Dec 17. PMID 393511
  2. Functional features of the C-terminal region of yeast ribosomal protein L5. Moradi H, et al. Mol Genet Genomics, 2008 Oct. PMID 18751732
  3. Differentiating between near- and non-cognate codons in Saccharomyces cerevisiae. Plant EP, et al. PLoS One, 2007 Jun 13. PMID 17565370, Free PMC Article
  4. A second-site mutation at glutamate-257 that restores the function of the mutant yeast ribosomal protein L5 containing lysine-270,271-->arginine. Yeh LC, et al. Biochim Biophys Acta, 1999 Dec 23. PMID 10673025
  5. Involvement of lysine 270 and lysine 271 of yeast 5S rRNA binding protein in RNA binding and ribosome assembly. Yeh LC, et al. Biochim Biophys Acta, 1996 Aug 14. PMID 8764831

See all (193) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion of Cgr1 results in inhibition of 5S ribonucleoprotein(RNP) rotation, but suppressor mutations mapping in factors Rpf2, Rrs1, and Rpl5, stabilizing the pre-rotational stage of the 5S RNP, partly overcome this defect.
    Title: Suppressor mutations in Rpf2-Rrs1 or Rpl5 bypass the Cgr1 function for pre-ribosomal 5S RNP-rotation.
  2. study identifies a transport adaptor, symportin 1 (Syo1)Ydl063c, that facilitates synchronized coimport of the 5S-rRNA binding proteins Rpl5 and Rpl11; symportin-mediated coimport of Rpl5-Rpl11 could ensure coordinated and stoichiometric incorporation of these proteins into pre-60S ribosomes
    Title: Synchronizing nuclear import of ribosomal proteins with ribosome assembly.
  3. identified a ribonucleoprotein neighborhood in preribosomes that contains two ribosome assembly factors, Rpf2 and Rrs1, two ribosomal proteins, rpL5 and rpL11, and 5S rRNA
    Title: Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5S rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5S rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm EXP
Inferred from Experiment
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus EXP
Inferred from Experiment
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
60S ribosomal protein uL18 RPL5
NP_015194.1
  • Ribosomal 60S subunit protein L5; nascent Rpl5p is bound by specific chaperone Syo1p during translation; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    303121..304014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183945.1 → NP_015194.1  60S ribosomal protein uL18 RPL5

    See identical proteins and their annotated locations for NP_015194.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3N6, P26321
    UniProtKB/TrEMBL
    B3LKU4
    Conserved Domains (1) summary
    PTZ00069
    Location:1 → 282
    PTZ00069; 60S ribosomal protein L5; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26321.4

Gene LinkOut

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