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TGS1 RNA methyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855946, updated on 14-Nov-2024

Summary

Official Symbol
TGS1
Official Full Name
RNA methyltransferase
Primary source
SGD:S000006078
Locus tag
YPL157W
See related
AllianceGenome:SGD:S000006078; FungiDB:YPL157W; VEuPathDB:YPL157W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA methyltransferase activity. Involved in several processes, including RNA processing; nucleologenesis; and regulation of telomere maintenance via telomerase. Located in nucleolus. Orthologous to human TGS1 (trimethylguanosine synthase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See TGS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (254814..255761)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Pet20p Neighboring gene Aim44p Neighboring gene pheromone-regulated protein PRM4 Neighboring gene Kip2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA cap trimethylguanosine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA cap trimethylguanosine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in 7-methylguanosine cap hypermethylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in 7-methylguanosine cap hypermethylation IEA
Inferred from Electronic Annotation
more info
 
involved_in 7-methylguanosine cap hypermethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
 
involved_in nucleologenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of telomere maintenance via telomerase IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA methyltransferase
NP_015168.1
  • Trimethyl guanosine synthase, conserved nucleolar methyl transferase; converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs; interacts with Swm2p, which may confer substrate specificity on Tgs1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    254814..255761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183971.1NP_015168.1  TPA: RNA methyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015168.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3L1, Q12052
    UniProtKB/TrEMBL
    A6ZW96, C8ZIM1, N1NVF8
    Conserved Domains (1) summary
    pfam09445
    Location:98262
    Methyltransf_15; RNA cap guanine-N2 methyltransferase