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MF(ALPHA)1 Mf(Alpha)1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855914, updated on 18-Sep-2024

Summary

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Official Symbol
MF(ALPHA)1
Official Full Name
Mf(Alpha)1p
Primary source
SGD:S000006108
Locus tag
YPL187W
See related
AllianceGenome:SGD:S000006108; FungiDB:YPL187W; VEuPathDB:YPL187W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cupric ion binding activity and mating pheromone activity. Involved in pheromone-dependent signal transduction involved in conjugation with cellular fusion. Located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MF(ALPHA)1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (193648..194145)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene putative O-acyltransferase Neighboring gene NADH kinase Neighboring gene Uip4p Neighboring gene Mrn1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functionality of the Paracoccidioides mating α-pheromone-receptor system. Gomes-Rezende JA, et al. PLoS One, 2012. PMID 23056569, Free PMC Article
  2. Position one analogs of the Saccharomyces cerevisiae tridecapeptide pheromone. Zhang YL, et al. J Pept Res, 1997 Nov. PMID 9401915
  3. Yeast alpha mating factor structure-activity relationship derived from genetically selected peptide agonists and antagonists of Ste2p. Manfredi JP, et al. Mol Cell Biol, 1996 Sep. PMID 8756627, Free PMC Article
  4. Probing the functional conformation of the tridecapeptide mating pheromone of Saccharomyces cerevisiae through study of disulfide-constrained analogs. Xue CB, et al. Int J Pept Protein Res, 1996 Mar. PMID 8740961
  5. Histidine2 of the alpha-factor of Saccharomyces cerevisiae is not essential for binding to its receptor or for biological activity. Levin Y, et al. Biochemistry, 1993 Aug 17. PMID 8394129

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The loss of viability observed in telomerase-deficient haploids and diploids is less severe when both MATa and MATalpha are co-expressed than when a single MAT allele is expressed.
    Title: Mating type influences chromosome loss and replicative senescence in telomerase-deficient budding yeast by Dnl4-dependent telomere fusion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cupric ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mating pheromone activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mating pheromone activity IEA
Inferred from Electronic Annotation
more info
  
enables mating pheromone activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pheromone activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mating IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone-dependent signal transduction involved in conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sexual reproduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mf(Alpha)1p
NP_015137.1
  • Alpha-factor mating pheromone made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor; binds copper(II) ions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    193648..194145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184001.1 → NP_015137.1  TPA: Mf(Alpha)1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015137.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3I2, P01149, P25041
    UniProtKB/TrEMBL
    C8ZIJ1, U3N3B0
    Conserved Domains (1) summary
    pfam05436
    Location:1 → 85
    MF_alpha_N; Mating factor alpha precursor N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01149.1

Gene LinkOut

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