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TYW1 putative tRNA 4-demethylwyosine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855894, updated on 2-Nov-2024

Summary

Official Symbol
TYW1
Official Full Name
putative tRNA 4-demethylwyosine synthase
Primary source
SGD:S000006128
Locus tag
YPL207W
See related
AllianceGenome:SGD:S000006128; FungiDB:YPL207W; VEuPathDB:YPL207W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables S-adenosyl-L-methionine binding activity. Involved in wybutosine biosynthetic process. Located in endoplasmic reticulum. Orthologous to human TYW1 (tRNA-yW synthesizing protein 1 homolog) and TYW1B (tRNA-yW synthesizing protein 1 homolog B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See TYW1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (159909..162341)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene aurora kinase Neighboring gene protein-lysine N-methyltransferase Neighboring gene phosphatidylglycerol phospholipase Neighboring gene serine/threonine protein kinase HRR25

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 
enables S-adenosyl-L-methionine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables tRNA-4-demethylwyosine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in wybutosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in wybutosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in wybutosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
putative tRNA 4-demethylwyosine synthase
NP_015117.1
  • Iron-sulfur protein required for synthesis of wybutosine modified tRNA; wybutosine is a modified guanosine found at 3'-position adjacent to anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    159909..162341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184021.1NP_015117.1  TPA: putative tRNA 4-demethylwyosine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3G3, Q08960
    UniProtKB/TrEMBL
    A6ZW48, B3LKM3, C8ZIH2
    Conserved Domains (2) summary
    COG0731
    Location:445762
    Tyw1; Wyosine [tRNA(Phe)-imidazoG37] synthetase, radical SAM superfamily [Translation, ribosomal structure and biogenesis]
    pfam00258
    Location:207354
    Flavodoxin_1