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PUS1 pseudouridine synthase PUS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855889, updated on 11-Aug-2022

Summary

Gene symbol
PUS1
Gene description
pseudouridine synthase PUS1
Primary source
SGD:S000006133
Locus tag
YPL212C
See related
AllianceGenome:SGD:S000006133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables pseudouridine synthase activity. Involved in mRNA pseudouridine synthesis; snRNA pseudouridine synthesis; and tRNA pseudouridine synthesis. Located in nucleus. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PUS1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (151515..153149, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase Neighboring gene U2 snRNP complex subunit LEA1 Neighboring gene ribosome biosynthesis protein NIP7 Neighboring gene signal recognition particle subunit SRP72

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PUS1 gene: The PUS1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding HDA PubMed 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pseudouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in RNA modification IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
involved_in snRNA pseudouridine synthesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pseudouridine synthase PUS1
NP_015112.1
  • tRNA:pseudouridine synthase; introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; also acts on U2 snRNA; also pseudouridylates some mRNAs, and pseudouridylation level varies with growth phase; nuclear protein that appears to be involved in tRNA export; PUS1 has a paralog, PUS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    151515..153149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184026.1NP_015112.1  TPA: pseudouridine synthase PUS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015112.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F8, Q12211
    UniProtKB/TrEMBL
    A0A0L8VGL9, A0A8H4BUF4, A6ZW43, B3LKL8, C8ZIG7, N1NWM6
    Conserved Domains (1) summary
    cd02568
    Location:79407
    PseudoU_synth_PUS1_PUS2; Pseudouridine synthase, PUS1/ PUS2 like