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THI6 bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855887, updated on 4-Feb-2024

Summary

Gene symbol
THI6
Gene description
bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
Primary source
SGD:S000006135
Locus tag
YPL214C
See related
AllianceGenome:SGD:S000006135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables hydroxyethylthiazole kinase activity and thiamine-phosphate diphosphorylase activity. Involved in thiamine biosynthetic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See THI6 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (148569..150191, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cbp3p Neighboring gene U2 snRNP complex subunit LEA1 Neighboring gene pseudouridine synthase PUS1

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxyethylthiazole kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxyethylthiazole kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables thiamine-phosphate diphosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables thiamine-phosphate diphosphorylase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiamine-phosphate diphosphorylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in thiamine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase
NP_015110.1
  • Thiamine-phosphate diphosphorylase and hydroxyethylthiazole kinase; required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    148569..150191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184028.1NP_015110.1  TPA: bifunctional hydroxyethylthiazole kinase/thiamine-phosphate diphosphorylase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015110.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F6, P41835
    UniProtKB/TrEMBL
    A0A6A5Q5W5, A6ZW41, B3LKL6, C7GN41, C8ZIG5, G2WNX1, N1NW91
    Conserved Domains (2) summary
    TIGR00694
    Location:255529
    thiM; hydroxyethylthiazole kinase
    TIGR00693
    Location:11225
    thiE; thiamine-phosphate diphosphorylase