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SAR1 Arf family GTPase SAR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855883, updated on 18-Jan-2023

Summary

Gene symbol
SAR1
Gene description
Arf family GTPase SAR1
Primary source
SGD:S000006139
Locus tag
YPL218W
See related
AllianceGenome:SGD:S000006139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase activity. Involved in several processes, including mitochondrion organization; nuclear envelope organization; and regulation of COPII vesicle coating. Located in endoplasmic reticulum exit site and mitochondria-associated endoplasmic reticulum membrane. Part of COPII vesicle coat. Used to study chylomicron retention disease. Human ortholog(s) of this gene implicated in chylomicron retention disease. Orthologous to human SAR1A (secretion associated Ras related GTPase 1A) and SAR1B (secretion associated Ras related GTPase 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SAR1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
2
Sequence:
Chromosome: XVI; NC_001148.4 (138698..139409)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L1A Neighboring gene Pcl8p Neighboring gene GTPase BMS1 Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SAR1 gene: The SAR1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial fission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein exit from endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of COPII vesicle coating IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of COPII vesicle coat IDA
Inferred from Direct Assay
more info
PubMed 
located_in ER to Golgi transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondria-associated endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Arf family GTPase SAR1
NP_015106.1
  • ARF family GTPase; component of the COPII vesicle coat; required for transport vesicle formation during ER to Golgi protein transport; lowers membrane rigidity aiding vesicle formation; localizes to ER-mitochondrial contact sites where it enhances membrane curvature, thereby reducing contact size via its N-terminal amphipathic helix; regulates mitochondrial fission and fusion dynamics

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    138698..139409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184032.1NP_015106.1  TPA: Arf family GTPase SAR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015106.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3F2, P20606
    UniProtKB/TrEMBL
    A0A0L8VGK2, A0A8B8V0L0, A6ZW37, B3LKL2, G2WNW7, N1NVN1
    Conserved Domains (1) summary
    smart00178
    Location:7190
    SAR; Sar1p-like members of the Ras-family of small GTPases