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PLC1 phosphatidylinositol phospholipase C [ Saccharomyces cerevisiae S288C ]

Gene ID: 855860, updated on 30-Jun-2022

Summary

Gene symbol
PLC1
Gene description
phosphatidylinositol phospholipase C
Primary source
SGD:S000006189
Locus tag
YPL268W
See related
AllianceGenome:SGD:S000006189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol phospholipase C activity. Involved in several processes, including inositol phosphate biosynthetic process; protein localization to kinetochore; and signal transduction involved in filamentous growth. Located in kinetochore. Human ortholog(s) of this gene implicated in several diseases, including developmental and epileptic encephalopathy 12; familial cold autoinflammatory syndrome 3; myelodysplastic syndrome; nonsyndromic congenital nail disorder 3; and spermatogenic failure 17. Orthologous to several human genes including PLCD4 (phospholipase C delta 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See PLC1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (35236..37845)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette permease MDL2 Neighboring gene Kar9p Neighboring gene Acm1p Neighboring gene putative dimethyladenosine transferase

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the PLC1 gene: The PLC1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol phospholipase C activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol phospholipase C
NP_015055.1
  • Phospholipase C; hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes; Plc1p and inositol polyphosphates are required for acetyl-CoA homeostasis which regulates global histone acetylation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    35236..37845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184082.1NP_015055.1  TPA: phosphatidylinositol phospholipase C [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015055.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P32383
    Conserved Domains (4) summary
    cd00275
    Location:732868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08598
    Location:379688
    PI-PLC1c_yeast; Catalytic domain of putative yeast phosphatidylinositide-specific phospholipases C
    PLN02952
    Location:284856
    PLN02952; phosphoinositide phospholipase C
    cd13360
    Location:124224
    PH_PLC_fungal; Fungal Phospholipase C (PLC) pleckstrin homology (PH) domain