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COS10 Cos10p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855812, updated on 7-Jun-2026
Official Symbol
COS10
Official Full Name
Cos10p
Primary source
SGD:S000005358
Locus tag
YNR075W
See related
AllianceGenome:SGD:S000005358; FungiDB:YNR075W; VEuPathDB:YNR075W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in endocytosis. Located in endoplasmic reticulum and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See COS10 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (779916..781040)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative mannitol dehydrogenase Neighboring gene Aif1p Neighboring gene uncharacterized protein Neighboring gene seripauperin PAU6

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification and characterization of Saccharomyces cerevisiae mutants defective in fluid-phase endocytosis. Wiederkehr A, et al. Yeast, 2001 Jun. PMID 11378903
  2. ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. Spode I, et al. J Mol Biol, 2002 May 31. PMID 12051917
  3. An evolutionary scenario for one of the largest yeast gene families. Despons L, et al. Trends Genet, 2006 Jan. PMID 16269202
  4. A family of tetraspans organizes cargo for sorting into multivesicular bodies. MacDonald C, et al. Dev Cell, 2015 May 4. PMID 25942624, Free PMC Article
  5. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope HDA PubMed 
Preferred Names
Cos10p
NP_014473.1
  • Endosomal protein involved in turnover of plasma membrane proteins; member of the DUP380 subfamily of conserved, often subtelomeric COS genes; required for the multivesicular vesicle body sorting pathway that internalizes plasma membrane proteins for degradation; Cos proteins provide ubiquitin in trans for nonubiquitinated cargo proteins

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    779916..781040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183252.1 → NP_014473.1  Cos10p

    See identical proteins and their annotated locations for NP_014473.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Q0, P52924
    UniProtKB/TrEMBL
    A6ZSE9, B5VR98, C7GKY7, C8ZFW5, N1NYA9
    Conserved Domains (1) summary
    pfam00674
    Location:66 → 160
    DUP; DUP family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52924.1

Gene LinkOut

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