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PDR18 ATP-binding cassette multidrug transporter PDR18 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855807, updated on 5-Aug-2018

Summary

Gene symbol
PDR18
Gene description
ATP-binding cassette multidrug transporter PDR18
Primary source
SGD:S000005353
Locus tag
YNR070W
Gene type
protein coding
RNA name
ATP-binding cassette multidrug transporter PDR18
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See PDR18 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (765375..769376)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene Bsc5p Neighboring gene aldose 1-epimerase superfamily protein Neighboring gene hexose transporter HXT17

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
ATPase activity, coupled to transmembrane movement of substances IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase activity, coupled to transmembrane movement of substances IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
xenobiotic transmembrane transporting ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
drug transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
drug transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to drug IMP
Inferred from Mutant Phenotype
more info
PubMed 
sterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sterol import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
xenobiotic transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane ISM
Inferred from Sequence Model
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette multidrug transporter PDR18
NP_014468.3
  • Putative transporter of the ATP-binding cassette (ABC) family; role in plasma membrane sterol incorporation; implicated in pleiotropic drug resistance; provides resistance to ethanol stress and contributes to a decreased intracellular accumulation of ethanol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    765375..769376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183247.4NP_014468.3  TPA: ATP-binding cassette multidrug transporter PDR18 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014468.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53756
    Conserved Domains (5) summary
    cd03232
    Location:727953
    ABCG_PDR_domain2; Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters
    cd03233
    Location:34263
    ABCG_PDR_domain1; First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters
    TIGR00956
    Location:11333
    3a01205; Pleiotropic Drug Resistance (PDR) Family protein
    pfam01061
    Location:378577
    ABC2_membrane; ABC-2 type transporter
    pfam06422
    Location:592686
    PDR_CDR; CDR ABC transporter
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