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CDK10 cyclin dependent kinase 10 [ Homo sapiens (human) ]

Gene ID: 8558, updated on 1-Aug-2020

Summary

Official Symbol
CDK10provided by HGNC
Official Full Name
cyclin dependent kinase 10provided by HGNC
Primary source
HGNC:HGNC:1770
See related
Ensembl:ENSG00000185324 MIM:603464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALSAS; PISSLRE
Summary
The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Expression
Ubiquitous expression in duodenum (RPKM 16.8), thyroid (RPKM 15.2) and 25 other tissues See more
Orthologs

Genomic context

See CDK10 in Genome Data Viewer
Location:
16q24.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (89686612..89696354)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (89753076..89762772)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene spermatogenesis associated 33 Neighboring gene long intergenic non-protein coding RNA 2166 Neighboring gene spermatogenesis associated 2 like Neighboring gene VPS9 domain containing 1 Neighboring gene VPS9D1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
AL KAISSI SYNDROME
MedGen: C4540156 OMIM: 617694 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
NHGRI GWA Catalog
Genome-wide association study identifies three loci associated with melanoma risk.
NHGRI GWA Catalog
Genome-wide association study identifies three new melanoma susceptibility loci.
NHGRI GWA Catalog
Identification of a melanoma susceptibility locus and somatic mutation in TET2.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of cyclin-dependent kinase 10 (CDK10) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
traversing start control point of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 10
Names
CDC2-related protein kinase
cell division protein kinase 10
cyclin-dependent kinase (CDC2-like) 10
cyclin-dependent kinase related protein
serine/threonine protein kinase PISSLRE
NP_001092003.2
NP_001153839.1
NP_443713.2
NP_443714.3
XP_006721371.1
XP_006721373.1
XP_011521707.1
XP_011521708.1
XP_011521709.1
XP_011521710.1
XP_011521712.1
XP_011521713.1
XP_011521714.1
XP_011521715.1
XP_011521716.1
XP_011521717.1
XP_011521718.1
XP_011521719.1
XP_016879295.1
XP_016879296.1
XP_016879297.1
XP_016879298.1
XP_016879299.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098533.3NP_001092003.2  cyclin-dependent kinase 10 isoform c

    See identical proteins and their annotated locations for NP_001092003.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) uses an alternate donor splice site at the first exon resulting in translation from a downstream start codon, and uses an alternate donor splice site in the 3' coding region, compared to variant a. The resulting isoform (c) has a shorter N-terminus and lacks a 6-aa segment near the C-terminus, compared to isoform a.
    Source sequence(s)
    BC017342
    UniProtKB/Swiss-Prot
    Q15131
    UniProtKB/TrEMBL
    B7Z537
    Conserved Domains (1) summary
    cl21453
    Location:1262
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001160367.2NP_001153839.1  cyclin-dependent kinase 10 isoform d

    See identical proteins and their annotated locations for NP_001153839.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) uses an alternate donor splice site at the first exon resulting in translation from downstream start codon, compared to variant a. The resulting isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC010538, AK298386, BC017342
    UniProtKB/Swiss-Prot
    Q15131
    UniProtKB/TrEMBL
    B7Z537
    Related
    ENSP00000329957.8, ENST00000331006.12
    Conserved Domains (1) summary
    cd07845
    Location:1268
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  3. NM_052987.4NP_443713.2  cyclin-dependent kinase 10 isoform b

    See identical proteins and their annotated locations for NP_443713.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) uses an alternate donor splice site at the first exon resulting in translation from a downstream start codon, and uses an alternate acceptor splice site at the last exon, compared to variant a. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    BC017342, L33264
    Consensus CDS
    CCDS32514.2
    UniProtKB/Swiss-Prot
    Q15131
    Related
    ENSP00000424415.1, ENST00000505473.5
    Conserved Domains (1) summary
    cl21453
    Location:1257
    PKc_like; Protein Kinases, catalytic domain
  4. NM_052988.5NP_443714.3  cyclin-dependent kinase 10 isoform a

    See identical proteins and their annotated locations for NP_443714.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK298386, BC017342
    Consensus CDS
    CCDS10984.2
    UniProtKB/Swiss-Prot
    Q15131
    UniProtKB/TrEMBL
    B7Z537
    Related
    ENSP00000338673.7, ENST00000353379.12
    Conserved Domains (1) summary
    cd07845
    Location:31339
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10

RNA

  1. NR_027702.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) lacks the second exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK296631, AK298386, BC017342
    Related
    ENST00000510811.6
  2. NR_027703.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (f) lacks the second exon and uses an alternate acceptor splice site at the last exon, compared to variant a. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant a, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK298386, BC025301

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    89686612..89696354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023806.1XP_016879295.1  cyclin-dependent kinase 10 isoform X5

    Conserved Domains (2) summary
    cd07845
    Location:16334
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PTZ00024
    Location:16331
    PTZ00024; cyclin-dependent protein kinase; Provisional
  2. XM_011523410.2XP_011521712.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521712.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  3. XM_011523412.1XP_011521714.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521714.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  4. XM_011523411.2XP_011521713.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521713.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  5. XM_011523416.2XP_011521718.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521718.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  6. XM_017023808.1XP_016879297.1  cyclin-dependent kinase 10 isoform X10

    UniProtKB/Swiss-Prot
    Q15131
    Conserved Domains (1) summary
    cd07845
    Location:1268
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  7. XM_011523415.3XP_011521717.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521717.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  8. XM_017023809.2XP_016879298.1  cyclin-dependent kinase 10 isoform X11

    UniProtKB/Swiss-Prot
    Q15131
    Conserved Domains (1) summary
    cl21453
    Location:1262
    PKc_like; Protein Kinases, catalytic domain
  9. XM_011523405.3XP_011521707.1  cyclin-dependent kinase 10 isoform X1

    Conserved Domains (2) summary
    cd07845
    Location:31371
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PTZ00024
    Location:43368
    PTZ00024; cyclin-dependent protein kinase; Provisional
  10. XM_011523407.3XP_011521709.1  cyclin-dependent kinase 10 isoform X3

    Conserved Domains (2) summary
    cd07845
    Location:31360
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PTZ00024
    Location:43360
    PTZ00024; cyclin-dependent protein kinase; Provisional
  11. XM_011523406.3XP_011521708.1  cyclin-dependent kinase 10 isoform X2

    Conserved Domains (2) summary
    cd07845
    Location:31365
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PTZ00024
    Location:43362
    PTZ00024; cyclin-dependent protein kinase; Provisional
  12. XM_011523408.3XP_011521710.1  cyclin-dependent kinase 10 isoform X4

    Conserved Domains (2) summary
    cd07845
    Location:31354
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PTZ00024
    Location:43354
    PTZ00024; cyclin-dependent protein kinase; Provisional
  13. XM_006721310.3XP_006721373.1  cyclin-dependent kinase 10 isoform X7

    Related
    ENST00000505733.5
    Conserved Domains (2) summary
    cd07845
    Location:31328
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
    PLN00009
    Location:38325
    PLN00009; cyclin-dependent kinase A; Provisional
  14. XM_006721308.3XP_006721371.1  cyclin-dependent kinase 10 isoform X6

    Conserved Domains (1) summary
    cd07845
    Location:31333
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  15. XM_017023807.2XP_016879296.1  cyclin-dependent kinase 10 isoform X8

  16. XM_011523417.3XP_011521719.1  cyclin-dependent kinase 10 isoform X13

    Conserved Domains (2) summary
    smart00220
    Location:39225
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:31223
    PKc_like; Protein Kinases, catalytic domain
  17. XM_011523413.2XP_011521715.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521715.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  18. XM_011523414.2XP_011521716.1  cyclin-dependent kinase 10 isoform X9

    See identical proteins and their annotated locations for XP_011521716.1

    Conserved Domains (1) summary
    cd07845
    Location:1300
    STKc_CDK10; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10
  19. XM_017023810.1XP_016879299.1  cyclin-dependent kinase 10 isoform X12

    UniProtKB/Swiss-Prot
    Q15131
    Conserved Domains (1) summary
    cl21453
    Location:1257
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_003674.2: Suppressed sequence

    Description
    NM_003674.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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