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HOL1 Hol1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855792, updated on 18-Sep-2024

Summary

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Official Symbol
HOL1
Official Full Name
Hol1p
Primary source
SGD:S000005338
Locus tag
YNR055C
See related
AllianceGenome:SGD:S000005338; FungiDB:YNR055C; VEuPathDB:YNR055C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables alcohol transmembrane transporter activity and inorganic cation transmembrane transporter activity. Involved in cation transport and organic hydroxy compound transport. Located in cell periphery; fungal-type vacuole; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HOL1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (728426..730186, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene RNA-binding ATPase activator ESF2 Neighboring gene tRNA-Leu Neighboring gene Bio5p Neighboring gene dethiobiotin synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amino acid substitutions in membrane-spanning domains of Hol1, a member of the major facilitator superfamily of transporters, confer nonselective cation uptake in Saccharomyces cerevisiae. Wright MB, et al. J Bacteriol, 1996 Dec. PMID 8955402, Free PMC Article
  2. HOL1 mutations confer novel ion transport in Saccharomyces cerevisiae. Gaber RF, et al. Mol Cell Biol, 1990 Feb. PMID 2405251, Free PMC Article
  3. Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1. Vindu A, et al. Mol Cell, 2021 Oct 7. PMID 34375581, Free PMC Article
  4. Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. Nelissen B, et al. FEBS Lett, 1995 Dec 18. PMID 8543057
  5. Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering. Kuo D, et al. Genome Biol, 2010. PMID 20653936, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1.
    Title: Translational autoregulation of the S. cerevisiae high-affinity polyamine transporter Hol1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables alcohol transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inorganic cation transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables polyamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organic hydroxy compound transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyamine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell periphery HDA PubMed 
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Hol1p
NP_014453.3
  • Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; mutations in membrane-spanning domains permit cation and histidinol uptake

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    728426..730186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183232.3 → NP_014453.3  TPA: Hol1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014453.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1N0, P53389
    UniProtKB/TrEMBL
    A6ZSC9, B5VR80, C7GIZ0, C8ZFT4, N1NZT7
    Conserved Domains (1) summary
    cd17323
    Location:67 → 569
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53389.1

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