LYS9 saccharopine dehydrogenase (NADP+, L-glutamate-forming) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LYS9
Official Full Name: saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Primary source: SGD:S000005333
Locus tag: YNR050C
See related: AllianceGenome:SGD:S000005333; FungiDB:YNR050C; VEuPathDB:YNR050C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LYS13
Summary: Enables saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity. Involved in lysine biosynthetic process via aminoadipic acid. Located in cell periphery and cytoplasm. Human ortholog(s) of this gene implicated in hyperlysinemia. Orthologous to human AASS (aminoadipate-semialdehyde synthase). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See LYS9 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (714048..715388, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alpha-Ketoglutarate (alpha-Kg) serves as the dead-end analogue of L-glutamate and is competitive vs L-glutamate and uncompetitive vs L-AASA and NADPH
Title: Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	IDA Inferred from Direct Assay more info	PubMed
enables saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	IEA Inferred from Electronic Annotation more info
enables saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity	RCA inferred from Reviewed Computational Analysis more info
enables saccharopine dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in L-lysine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-lysine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-lysine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in L-lysine biosynthetic process	RCA inferred from Reviewed Computational Analysis more info

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info

General protein information

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Preferred Names: saccharopine dehydrogenase (NADP+, L-glutamate-forming)

NP_014448.1

EC 1.5.1.10

Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

714048..715388 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183227.1 → NP_014448.1 saccharopine dehydrogenase (NADP+, L-glutamate-forming)

See identical proteins and their annotated locations for NP_014448.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1M5, E9P930, P38999

UniProtKB/TrEMBL

A6ZSC4, B3LPJ3, B5VR75, C7GLK7, C8ZFS9, G2WLA7, N1NZT3

Conserved Domains (1) summary

COG1748
Location:3 → 393

Lys9; Saccharopine dehydrogenase, NADP-dependent [Amino acid transport and metabolism]