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TRM112 RNA methylation protein TRM112 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855782, updated on 23-Apr-2026
Official Symbol
TRM112
Official Full Name
RNA methylation protein TRM112
Primary source
SGD:S000005329
Locus tag
YNR046W
See related
AllianceGenome:SGD:S000005329; FungiDB:YNR046W; VEuPathDB:YNR046W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to protein methyltransferase activity; rRNA (guanine) methyltransferase activity; and tRNA (guanine(10)-N2)-methyltransferase activity. Involved in RNA processing and peptidyl-glutamine methylation. Located in cytoplasm and nucleolus. Part of eRF1 methyltransferase complex and tRNA (m2G10) methyltransferase complex. Orthologous to human TRMT112 (tRNA methyltransferase activator subunit 11-2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See TRM112 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (707788..708195)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Aga1p Neighboring gene Pet494p Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene putative aminophospholipid translocase regulatory protein

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Production of yeast (m2G10) methyltransferase (Trm11 and Trm112 complex) in a wheat germ cell-free translation system. Okada K, et al. Nucleic Acids Symp Ser (Oxf), 2009. PMID 19749381
  2. Trmt112 gene expression in mouse embryonic development. Gu T, et al. Acta Histochem Cytochem, 2012 Apr 26. PMID 22685353, Free PMC Article
  3. Mechanism of activation of methyltransferases involved in translation by the Trm112 'hub' protein. Liger D, et al. Nucleic Acids Res, 2011 Aug. PMID 21478168, Free PMC Article
  4. Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. Chen C, et al. PLoS One, 2011. PMID 21687733, Free PMC Article
  5. Physical and functional interaction between the methyltransferase Bud23 and the essential DEAH-box RNA helicase Ecm16. Sardana R, et al. Mol Cell Biol, 2014 Jun. PMID 24710271, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
    Title: The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis.
  2. Trm112 is required for efficient ribosome synthesis and progression through mitosis
    Title: Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.
  3. Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast
    Title: Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast.
  4. The Ynr046w eRF1 methyltransferase subunit is shared by the tRNA methyltransferase Trm11p and probably by two other enzymes containing a Rossman fold
    Title: The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to rRNA (guanine) methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to tRNA (guanine(10)-N2)-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to tRNA (guanine(10)-N2)-methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA methyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of termination of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in rRNA (guanine-N7)-methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA (guanine-N7)-methylation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal small subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA wobble uridine modification IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eRF1 methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleolus HDA PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
part_of tRNA (m2G10) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of tRNA (m2G10) methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
Preferred Names
RNA methylation protein TRM112
NP_014444.1
  • Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; N7-methylates G1575 of 18S rRNA as complex with Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress; functional homolog of human TRMT112

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    707788..708195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183223.1 → NP_014444.1  RNA methylation protein TRM112

    See identical proteins and their annotated locations for NP_014444.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1M1, P53738
    UniProtKB/TrEMBL
    A6ZSC0, B3LPJ7, C7GLL1, C8ZFS5, G2WLA3, N1NZS7
    Conserved Domains (1) summary
    cd21089
    Location:2 → 130
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53738.1

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