U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MVD1 diphosphomevalonate decarboxylase MVD1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855779, updated on 17-May-2024

Summary

Gene symbol
MVD1
Gene description
diphosphomevalonate decarboxylase MVD1
Primary source
FungiDB:YNR043W
Locus tag
YNR043W
See related
SGD:S000005326; AllianceGenome:SGD:S000005326; VEuPathDB:YNR043W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ERG19
Summary
Enables diphosphomevalonate decarboxylase activity. Involved in sterol biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human MVD (mevalonate diphosphate decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MVD1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (701895..703085)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mrx15p Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene Aga1p Neighboring gene Pet494p

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables diphosphomevalonate decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables diphosphomevalonate decarboxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables diphosphomevalonate decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables diphosphomevalonate decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
is_active_in vacuole NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
diphosphomevalonate decarboxylase MVD1
NP_014441.1
  • Mevalonate pyrophosphate decarboxylase; essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    701895..703085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183220.1NP_014441.1  TPA: diphosphomevalonate decarboxylase MVD1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014441.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1L8, P32377, Q6B1C8
    UniProtKB/TrEMBL
    A0A8H4BY34, B3LPK0, C8ZFS2, N1P4U1
    Conserved Domains (1) summary
    TIGR01240
    Location:6328
    mevDPdecarb; diphosphomevalonate decarboxylase