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ATP23 putative metalloprotease [ Saccharomyces cerevisiae S288C ]

Gene ID: 855754, updated on 23-Apr-2026
Official Symbol
ATP23
Official Full Name
putative metalloprotease
Primary source
SGD:S000005303
Locus tag
YNR020C
See related
AllianceGenome:SGD:S000005303; FungiDB:YNR020C; VEuPathDB:YNR020C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Involved in mitochondrial protein processing and mitochondrial proton-transporting ATP synthase complex assembly. Located in mitochondrial intermembrane space. Orthologous to human ATP23 (ATP23 metallopeptidase and ATP synthase assembly factor homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See ATP23 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (667410..668222, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Rcf2p Neighboring gene sterol acyltransferase Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein bL9m MRPL50

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. T1121G Point Mutation in the Mitochondrial Gene COX1 Suppresses a Null Mutation in ATP23 Required for the Assembly of Yeast Mitochondrial ATP Synthase. Yang G, et al. Int J Mol Sci, 2022 Feb 19. PMID 35216443, Free PMC Article
  2. Atp23p and Atp10p coordinate to regulate the assembly of yeast mitochondrial ATP synthase. Yang G, et al. FASEB J, 2021 Jun. PMID 33956347, Free PMC Article
  3. Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. Weckbecker D, et al. EMBO J, 2012 Nov 14. PMID 22990235, Free PMC Article
  4. The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase. Zeng X, et al. Mol Biol Cell, 2007 Feb. PMID 17135290, Free PMC Article
  5. Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase. Osman C, et al. Mol Biol Cell, 2007 Feb. PMID 17135288, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Atp23 was identified as a novel substrate of Mia40. Oxidation of Atp23 is not essential for its import; an Atp23 variant in which all ten cysteine residues were replaced by serine residues still accumulates in mitochondria in a Mia40-dependent manner.
    Title: Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria.
  2. A new metalloprotease encoded by the nuclear ATP23 gene of Saccharomyces cerevisiae essential for expression of mitochondrial ATPase (F(1)-F(O) complex) was identified.
    Title: The metalloprotease encoded by ATP23 has a dual function in processing and assembly of subunit 6 of mitochondrial ATPase.
  3. The identification of a conserved metallopeptidase present in the intermembrane space, termed Atp23, which exerts dual activities during the biogenesis of the F(1)F(O)-ATP synthase was descibed.
    Title: Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1Fo-ATP synthase.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitochondrial protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial proton-transporting ATP synthase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
putative metalloprotease
NP_014417.3
  • Putative metalloprotease of the mitochondrial inner membrane; required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    667410..668222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183197.3 → NP_014417.3  putative metalloprotease

    See identical proteins and their annotated locations for NP_014417.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1P4R1
    Conserved Domains (1) summary
    pfam09768
    Location:91 → 266
    Peptidase_M76; Peptidase M76 family
Nucleotide Protein
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