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ACC1 acetyl-CoA carboxylase ACC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855750, updated on 18-Sep-2024

Summary

Official Symbol
ACC1
Official Full Name
acetyl-CoA carboxylase ACC1
Primary source
SGD:S000005299
Locus tag
YNR016C
See related
AllianceGenome:SGD:S000005299; FungiDB:YNR016C; VEuPathDB:YNR016C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ABP2; FAS3; MTR7
Summary
Enables acetyl-CoA carboxylase activity and biotin carboxylase activity. Involved in long-chain fatty acid biosynthetic process and protein import into nucleus. Located in endoplasmic reticulum membrane. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See ACC1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (654673..661374, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-dihydrouridine(20) synthase (NAD(+)) Neighboring gene protein transporter TIM23 Neighboring gene Rcf2p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables acetyl-CoA carboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables biotin carboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables biotin carboxylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in malonyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
acetyl-CoA carboxylase ACC1
NP_014413.1
  • Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    654673..661374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183193.1NP_014413.1  TPA: acetyl-CoA carboxylase ACC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014413.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1J1, Q00955
    UniProtKB/TrEMBL
    A6ZS90, B3LPM6, C7GLN9, N1P4Q3
    Conserved Domains (4) summary
    COG0439
    Location:59570
    AccC; Biotin carboxylase [Lipid transport and metabolism]
    COG0511
    Location:622769
    AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]
    pfam01039
    Location:15742118
    Carboxyl_trans; Carboxyl transferase domain
    pfam08326
    Location:7681479
    ACC_central; Acetyl-CoA carboxylase, central region