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SMM1 tRNA-dihydrouridine(20) synthase (NAD(+)) [ Saccharomyces cerevisiae S288C ]

Gene ID: 855749, updated on 18-Sep-2024

Summary

Official Symbol
SMM1
Official Full Name
tRNA-dihydrouridine(20) synthase (NAD(+))
Primary source
SGD:S000005298
Locus tag
YNR015W
See related
AllianceGenome:SGD:S000005298; FungiDB:YNR015W; VEuPathDB:YNR015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DUS2
Summary
Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Located in cytoplasm and nucleus. Orthologous to human DUS2 (dihydrouridine synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See SMM1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (653387..654541)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Pho91p Neighboring gene uncharacterized protein Neighboring gene acetyl-CoA carboxylase ACC1 Neighboring gene protein transporter TIM23

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables tRNA dihydrouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables tRNA dihydrouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables tRNA-dihydrouridine20 synthase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA dihydrouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA modification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA processing IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
tRNA-dihydrouridine(20) synthase (NAD(+))
NP_014412.1
  • Dihydrouridine synthase; member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of the D loop of cytoplasmic pre-tRNAs

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    653387..654541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183192.1NP_014412.1  TPA: tRNA-dihydrouridine(20) synthase (NAD(+)) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014412.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1J0, P53720
    UniProtKB/TrEMBL
    A6ZS89, B3LPM7, B5VR46, C7GLP0, G2WL72, N1NWS7
    Conserved Domains (1) summary
    cl21457
    Location:31355
    TIM; TIM-like beta/alpha barrel domains