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URK1 uridine kinase URK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855746, updated on 14-Nov-2024

Summary

Official Symbol
URK1
Official Full Name
uridine kinase URK1
Primary source
SGD:S000005295
Locus tag
YNR012W
See related
AllianceGenome:SGD:S000005295; FungiDB:YNR012W; VEuPathDB:YNR012W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables uridine kinase activity. Involved in pyrimidine-containing compound salvage. Located in cytoplasm and nucleus. Orthologous to human UCKL1 (uridine-cytidine kinase 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See URK1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (647432..648937)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Cse2p Neighboring gene DEAH-box RNA-dependent ATPase PRP2 Neighboring gene Pho91p Neighboring gene uncharacterized protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytidine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables uridine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables uridine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in CMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in CTP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in UMP salvage IEA
Inferred from Electronic Annotation
more info
 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in pyrimidine-containing compound salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyrimidine-containing compound salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uridine kinase URK1
NP_014409.1
  • Uridine/cytidine kinase; component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    647432..648937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183189.1NP_014409.1  TPA: uridine kinase URK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014409.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1I7, P27515
    UniProtKB/TrEMBL
    B5VR43, C7GLP3, N1NY55
    Conserved Domains (2) summary
    COG0035
    Location:280501
    Upp; Uracil phosphoribosyltransferase [Nucleotide transport and metabolism]
    TIGR00235
    Location:69260
    udk; uridine kinase