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ATG3 Atg3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855741, updated on 9-Jun-2019

Summary

Gene symbol
ATG3
Gene description
Atg3p
Primary source
SGD:S000005290
Locus tag
YNR007C
Gene type
protein coding
RNA name
Atg3p
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APG3; AUT1

Genomic context

See ATG3 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (639182..640114, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Swm2p Neighboring gene ESCRT-0 subunit protein VPS27 Neighboring gene phospholipid:diacylglycerol acyltransferase Neighboring gene Nrm1p

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - yeast, organism-specific biosystem (from KEGG)
    Autophagy - yeast, organism-specific biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
  • Autophagy - yeast, conserved biosystem (from KEGG)
    Autophagy - yeast, conserved biosystemAutophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophag...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
Atg8 ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Atg8 ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
C-terminal protein lipidation IDA
Inferred from Direct Assay
more info
PubMed 
C-terminal protein lipidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy IEA
Inferred from Electronic Annotation
more info
 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy of mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
late nucleophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
piecemeal microautophagy of the nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm HDA PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagophore IDA
Inferred from Direct Assay
more info
PubMed 
phagophore IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Atg3p
NP_014404.3
  • E2-like enzyme; involved in autophagy and cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt; interaction with Atg8p regulated by acetylation by NuA4 histone acetyltransferase Esa1p while attenuation of Atg3 acetylation is mediated by histone deacetylase Rpd3p; Atg12p-Atg5p conjugate enhances E2 activity of Atg3p by rearranging its catalytic site

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    639182..640114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183184.3NP_014404.3  TPA: Atg3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014404.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P40344
    Conserved Domains (3) summary
    pfam03986
    Location:2141
    Autophagy_N; Autophagocytosis associated protein (Atg3), N-terminal domain
    pfam03987
    Location:173235
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain
    pfam10381
    Location:283307
    Autophagy_C; Autophagocytosis associated protein C-terminal
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