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RPC34 DNA-directed RNA polymerase III subunit C34 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855737, updated on 23-Apr-2026
Official Symbol
RPC34
Official Full Name
DNA-directed RNA polymerase III subunit C34
Primary source
SGD:S000005286
Locus tag
YNR003C
See related
AllianceGenome:SGD:S000005286; FungiDB:YNR003C; VEuPathDB:YNR003C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III. Located in mitochondrion. Part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in immunodeficiency 101. Orthologous to human POLR3F (RNA polymerase III subunit F). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
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See RPC34 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (634344..635297, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene putative ammonium permease ATO2 Neighboring gene Swm2p Neighboring gene ESCRT-0 subunit protein VPS27

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An essential and specific subunit of RNA polymerase III (C) is encoded by gene RPC34 in Saccharomyces cerevisiae. Stettler S, et al. J Biol Chem, 1992 Oct 25. PMID 1400451
  2. RNA polymerase III interferes with Ty3 integration. Connolly CM, et al. FEBS Lett, 1997 Apr 1. PMID 9108309
  3. Dual role of the C34 subunit of RNA polymerase III in transcription initiation. Brun I, et al. EMBO J, 1997 Sep 15. PMID 9312031, Free PMC Article
  4. Twelve open reading frames revealed in the 23.6 kb segment flanking the centromere on the Saccharomyces cerevisiae chromosome XIV right arm. Verhasselt P, et al. Yeast, 1994 Oct. PMID 7900425
  5. Interaction between a complex of RNA polymerase III subunits and the 70-kDa component of transcription factor IIIB. Werner M, et al. J Biol Chem, 1993 Oct 5. PMID 8407894

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in termination of RNA polymerase III transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription initiation at RNA polymerase III promoter IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
Preferred Names
DNA-directed RNA polymerase III subunit C34
NP_014400.1
  • RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    634344..635297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183180.1 → NP_014400.1  DNA-directed RNA polymerase III subunit C34

    See identical proteins and their annotated locations for NP_014400.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1H9, P32910
    UniProtKB/TrEMBL
    A6ZS78, B3LPN6, B5VR36, C7GLQ1, C8ZFM9, G2WL61, N1NY47
    Conserved Domains (1) summary
    COG5111
    Location:4 → 317
    RPC34; DNA-directed RNA polymerase III, subunit C34 [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32910.1

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