LST8 TOR complex subunit LST8 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: LST8
Official Full Name: TOR complex subunit LST8
Primary source: SGD:S000004951
Locus tag: YNL006W
See related: AllianceGenome:SGD:S000004951; FungiDB:YNL006W; VEuPathDB:YNL006W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables protein serine/threonine kinase activator activity. Involved in several processes, including establishment or maintenance of actin cytoskeleton polarity; fungal-type cell wall organization; and intracellular signal transduction. Located in Golgi membrane; endosome membrane; and nuclear periphery. Part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See LST8 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (620067..620978)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p.
Title: Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p.
We propose that Gtr1p and Gtr2p are involved in epigenetic control of gene expression in the TOR signaling pathway.
Title: Genetic evidence that Ras-like GTPases, Gtr1p, and Gtr2p, are involved in epigenetic control of gene expression in Saccharomyces cerevisiae.
Rtg1/3p, Gln3p, and Gat1p can be differentially regulated through different nutrient-sensing pathways, such as TOR and retrograde signaling, and by multiple factors, such as Lst8p, which is suggested to have a role in connecting the RTG and TOR pathways
Title: Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TOR signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of actin cytoskeleton polarity	NAS Non-traceable Author Statement more info	PubMed
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondria-nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell growth	IPI Inferred from Physical Interaction more info	PubMed
involved_in regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
involved_in response to nutrient	NAS Non-traceable Author Statement more info	PubMed
involved_in signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in endosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TOR complex subunit LST8

NP_014392.3

Subunit of TORC1 and TORC2 involved in TOR signaling; TORC1 regulates nutrient responsive growth and TORC2 regulates plasma membrane (PM) homeostasis and cell-cycle dependent actin cytoskeleton polarization; negative regulator of Rtg1p/3p and Gln3p transcription factors and amino acid biosynthesis; binds to both Tor1p and Tor2p, regulating the integrity and kinase activity of TORC2; PM retention is dependent on Avo3p; WD-repeat protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

620067..620978

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182845.3 → NP_014392.3 TOR complex subunit LST8

See identical proteins and their annotated locations for NP_014392.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1H1, P41318

UniProtKB/TrEMBL

A6ZS70, B3LPP4, B5VR28, C7GJE5, C8ZFM0, G2WL53, N1NZM8

Conserved Domains (2) summary

cd00200
Location:4 → 278

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:36 → 73

7WD40; WD40 repeat [structural motif]