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LST8 TOR complex subunit LST8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855726, updated on 18-Sep-2024

Summary

Official Symbol
LST8
Official Full Name
TOR complex subunit LST8
Primary source
SGD:S000004951
Locus tag
YNL006W
See related
AllianceGenome:SGD:S000004951; FungiDB:YNL006W; VEuPathDB:YNL006W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein kinase activator activity. Involved in several processes, including TOR signaling; establishment or maintenance of actin cytoskeleton polarity; and mitochondria-nucleus signaling pathway. Located in Golgi membrane; endosome membrane; and nuclear periphery. Is extrinsic component of cytoplasmic side of plasma membrane. Part of TORC1 complex and TORC2 complex. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See LST8 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (620067..620978)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative ubiquitin-protein ligase ASI3 Neighboring gene type II HSP40 co-chaperone SIS1 Neighboring gene mitochondrial 54S ribosomal protein YmL2 Neighboring gene mRNA-binding protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondria-nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell growth IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of TORC1 complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
 
part_of TORC2 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosol HDA PubMed 
located_in endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
TOR complex subunit LST8
NP_014392.3
  • Subunit of TORC1 and TORC2 involved in TOR signaling; TORC1 regulates nutrient responsive growth and TORC2 regulates plasma membrane (PM) homeostasis and cell-cycle dependent actin cytoskeleton polarization; negative regulator of Rtg1p/3p and Gln3p transcription factors and amino acid biosynthesis; binds to both Tor1p and Tor2p, regulating the integrity and kinase activity of TORC2; PM retention is dependent on Avo3p; WD-repeat protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    620067..620978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182845.3NP_014392.3  TPA: TOR complex subunit LST8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014392.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1H1, P41318
    UniProtKB/TrEMBL
    A6ZS70, B3LPP4, B5VR28, C7GJE5, C8ZFM0, G2WL53, N1NZM8
    Conserved Domains (2) summary
    cd00200
    Location:4278
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:3673
    7WD40; WD40 repeat [structural motif]