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SIS1 type II HSP40 co-chaperone SIS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855725, updated on 3-Mar-2019

Summary

Gene symbol
SIS1
Gene description
type II HSP40 co-chaperone SIS1
Primary source
SGD:S000004952
Locus tag
YNL007C
Gene type
protein coding
RNA name
type II HSP40 co-chaperone SIS1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces

Genomic context

See SIS1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (618507..619565, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene isocitrate dehydrogenase (NADP(+)) IDP3 Neighboring gene putative ubiquitin-protein ligase ASI3 Neighboring gene TOR complex subunit LST8 Neighboring gene mitochondrial 54S ribosomal protein YmL2

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the SIS1 gene: The SIS1 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
misfolded protein transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear protein quality control by the ubiquitin-proteasome system IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein folding IDA
Inferred from Direct Assay
more info
PubMed 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
tRNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
type II HSP40 co-chaperone SIS1
NP_014391.1
  • Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    618507..619565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182846.1NP_014391.1  TPA: type II HSP40 co-chaperone SIS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014391.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25294
    Conserved Domains (3) summary
    cd10747
    Location:180340
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:2350
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:765
    DnaJ; DnaJ domain
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