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GALP galanin like peptide [ Homo sapiens (human) ]

Gene ID: 85569, updated on 25-Jan-2022

Summary

Official Symbol
GALPprovided by HGNC
Official Full Name
galanin like peptideprovided by HGNC
Primary source
HGNC:HGNC:24840
See related
Ensembl:ENSG00000197487 MIM:611178; AllianceGenome:HGNC:24840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the galanin family of neuropeptides. The encoded protein binds galanin receptors 1, 2 and 3 with the highest affinity for galanin receptor 3 and has been implicated in biological processes involving the central nervous system including hypothalamic regulation of metabolism and reproduction. A peptide encoded by a splice variant of this gene, termed alarin, has vasoactive properties, displays antimicrobial activity against E. coli, and may serve as a marker for neuroblastic tumors.[provided by RefSeq, Nov 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GALP in Genome Data Viewer
Location:
19q13.43
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56176008..56185775)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56687377..56697144)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 787 Neighboring gene Sharpr-MPRA regulatory region 1998 Neighboring gene zinc finger protein 444 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6329 Neighboring gene zinc finger and SCAN domain containing 5B

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in behavioral response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of appetite IEA
Inferred from Electronic Annotation
more info
 
involved_in response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galanin-like peptide
Names
alarin
gal-like peptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029931.2 RefSeqGene

    Range
    4989..14756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145546.2NP_001139018.1  galanin-like peptide isoform 2 precursor

    See identical proteins and their annotated locations for NP_001139018.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus compared to isoform 1. This variant, termed alarin, is a candidate for nonsense-mediated mRNA decay (NMD) but is being represented as protein-coding based on evidence supporting the transcript and protein described in PMID 16954604. The exon structure of this variant is based on Figure 1 from PMID 16954604.
    Source sequence(s)
    AC024580, AF188493
    Consensus CDS
    CCDS46202.1
    UniProtKB/Swiss-Prot
    Q9UBC7
    Related
    ENSP00000411521.1, ENST00000440823.1
  2. NM_033106.4NP_149097.1  galanin-like peptide isoform 1 precursor

    See identical proteins and their annotated locations for NP_149097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC024580, AF188493
    Consensus CDS
    CCDS12940.1
    UniProtKB/Swiss-Prot
    Q9UBC7
    Related
    ENSP00000349884.2, ENST00000357330.7
    Conserved Domains (1) summary
    pfam01296
    Location:3345
    Galanin; Galanin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    56176008..56185775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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