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MSG5 tyrosine/serine/threonine protein phosphatase MSG5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855674, updated on 17-May-2024

Summary

Gene symbol
MSG5
Gene description
tyrosine/serine/threonine protein phosphatase MSG5
Primary source
FungiDB:YNL053W
Locus tag
YNL053W
See related
SGD:S000004998; AllianceGenome:SGD:S000004998; VEuPathDB:YNL053W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including regulation of MAPK export from nucleus; regulation of fungal-type cell wall organization; and regulation of signal transduction. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in breast cancer and hypogonadotropic hypogonadism 19 with or without anosmia. Orthologous to several human genes including DUSP1 (dual specificity phosphatase 1); DUSP10 (dual specificity phosphatase 10); and DUSP16 (dual specificity phosphatase 16). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See MSG5 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (529942..531411)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Vac7p Neighboring gene cytochrome c oxidase subunit Va Neighboring gene Golgi transport complex subunit COG5

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables MAP kinase tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tyrosine/serine/threonine protein phosphatase MSG5
NP_014345.3
  • Dual-specificity protein phosphatase; maintains low levels of both basal and induced cell integrity pathway signaling by dephosphorylation of the Slt2p MAPK; reciprocally regulated by Slt2p through phosphorylation; minor role with Ptp2p in the adaptive response to pheromone through the dephosphorylation of the Fus3p MAPK with major contribution by Ptp3p; inhibits the nuclear accumulation of Fus3p; two isoforms exist as the result of alternative translation initiation starts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    529942..531411
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182892.3NP_014345.3  TPA: tyrosine/serine/threonine protein phosphatase MSG5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014345.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1C6, P38590
    UniProtKB/TrEMBL
    A0A8H4BXZ7, A6ZS25, B3LNR4, B5VQY9, C7GLU8, C8ZGH5, N1NXK7
    Conserved Domains (1) summary
    cd14521
    Location:230373
    DSP_fungal_SDP1-like; dual specificity phosphatase domain of fungal dual specificity protein phosphatase SDP1, MSG5, and similar proteins