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YDJ1 type I HSP40 co-chaperone YDJ1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855661, updated on 7-Apr-2019

Summary

Gene symbol
YDJ1
Gene description
type I HSP40 co-chaperone YDJ1
Primary source
SGD:S000005008
Locus tag
YNL064C
Gene type
protein coding
RNA name
type I HSP40 co-chaperone YDJ1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HSP40; MAB3; MAS5

Genomic context

See YDJ1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (505868..507097, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative glucosidase SUN4 Neighboring gene Aqr1p Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene tRNA 1-methyladenosine methyltransferase subunit GCD10

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the YDJ1 gene: The YDJ1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
unfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' protein folding IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ATPase activity IEA
Inferred from Electronic Annotation
more info
 
protein folding IEA
Inferred from Electronic Annotation
more info
 
protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to ER IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
response to heat IEA
Inferred from Electronic Annotation
more info
 
tRNA import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent ERAD pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
TRC complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol HDA PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
type I HSP40 co-chaperone YDJ1
NP_014335.1
  • Type I HSP40 co-chaperone; involved in regulation of HSP90 and HSP70 functions; acts as an adaptor that helps Rsp5p recognize cytosolic misfolded proteins for ubiquitination after heat shock; critical for determining cell size at Start as a function of growth rate; involved in protein translocation across membranes; member of the DnaJ family; chimeric protein in which human p58IPK J domain replaces yeast Ydj1p J domain can complement yeast ydj1 mutant

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    505868..507097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182902.1NP_014335.1  TPA: type I HSP40 co-chaperone YDJ1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014335.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P25491
    Conserved Domains (4) summary
    cd10719
    Location:143208
    DnaJ_zf; Zinc finger domain of DnaJ and HSP40
    cd10747
    Location:114338
    DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    COG0484
    Location:2368
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    pfam00226
    Location:767
    DnaJ; DnaJ domain
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