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APP1 phosphatidate phosphatase APP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855630, updated on 7-Jun-2026
Official Symbol
APP1
Official Full Name
phosphatidate phosphatase APP1
Primary source
SGD:S000005038
Locus tag
YNL094W
See related
AllianceGenome:SGD:S000005038; FungiDB:YNL094W; VEuPathDB:YNL094W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidate phosphatase activity. Involved in lipid metabolic process. Located in actin cortical patch. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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See APP1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (447611..449374)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein eS7 RPS7B Neighboring gene uncharacterized protein Neighboring gene Rab family GTPase YPT53 Neighboring gene S-adenosylmethionine-dependent methyltransferase

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. RNA-binding proteins that inhibit RNA virus infection. Zhu J, et al. Proc Natl Acad Sci U S A, 2007 Feb 27. PMID 17360619, Free PMC Article
  2. Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. Fazi B, et al. J Biol Chem, 2002 Feb 15. PMID 11668184
  3. Age-dependent decline in stress response capacity revealed by proteins dynamics analysis. Chen K, et al. Sci Rep, 2020 Sep 16. PMID 32939000, Free PMC Article
  4. Interaction of the Saccharomyces cerevisiae cortical actin patch protein Rvs167p with proteins involved in ER to Golgi vesicle trafficking. Friesen H, et al. Genetics, 2005 Jun. PMID 15802519, Free PMC Article
  5. Cross-talk phosphorylations by protein kinase C and Pho85p-Pho80p protein kinase regulate Pah1p phosphatidate phosphatase abundance in Saccharomyces cerevisiae. Su WM, et al. J Biol Chem, 2014 Jul 4. PMID 24876385, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cortical patch IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
phosphatidate phosphatase APP1
NP_014305.1
  • Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    447611..449374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182932.1 → NP_014305.1  phosphatidate phosphatase APP1

    See identical proteins and their annotated locations for NP_014305.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W186, P53933
    UniProtKB/TrEMBL
    A6ZRY7, B3LNV2, B5VQU9, E9P9B9, G2WM11, N1NXH1
    Conserved Domains (1) summary
    COG4850
    Location:91 → 488
    App1; Phosphatidate phosphatase APP1 [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53933.1

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