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POL1 DNA-directed DNA polymerase alpha catalytic subunit POL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855621, updated on 8-Nov-2020

Summary

Gene symbol
POL1
Gene description
DNA-directed DNA polymerase alpha catalytic subunit POL1
Primary source
SGD:S000005046
Locus tag
YNL102W
Gene type
protein coding
RNA name
DNA-directed DNA polymerase alpha catalytic subunit POL1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC17; CRT5; HPR3

Genomic context

See POL1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (430087..434493)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 2-isopropylmalate synthase LEU4 Neighboring gene Met4p Neighboring gene Avt4p Neighboring gene Mic27p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the POL1 gene: The POL1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.

Gene Ontology Provided by GO

Function Evidence Code Pubs
4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
purine nucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine nucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA replication initiation IC
Inferred by Curator
more info
PubMed 
DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
RNA-dependent DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lagging strand elongation IC
Inferred by Curator
more info
PubMed 
leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed DNA polymerase alpha catalytic subunit POL1
NP_014297.3
  • Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    430087..434493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182940.3NP_014297.3  TPA: DNA-directed DNA polymerase alpha catalytic subunit POL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014297.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13382
    Conserved Domains (5) summary
    cd05776
    Location:534776
    DNA_polB_alpha_exo; inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase alpha, a family-B DNA polymerase
    cd05532
    Location:8371244
    POLBc_alpha; DNA polymerase type-B alpha subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) alpha is almost exclusively ...
    TIGR00592
    Location:291227
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12691463
    zf-DNA_Pol; DNA Polymerase alpha zinc finger
    pfam12254
    Location:1176
    DNA_pol_alpha_N; DNA polymerase alpha subunit p180 N terminal
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