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POL1 DNA-directed DNA polymerase alpha catalytic subunit POL1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855621, updated on 3-Dec-2023

Summary

Gene symbol
POL1
Gene description
DNA-directed DNA polymerase alpha catalytic subunit POL1
Primary source
SGD:S000005046
Locus tag
YNL102W
See related
AllianceGenome:SGD:S000005046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC17; CRT5; HPR3
Summary
Enables DNA-directed DNA polymerase activity. Involved in DNA metabolic process and premeiotic DNA replication. Located in replication fork. Part of alpha DNA polymerase:primase complex. Human ortholog(s) of this gene implicated in Van Esch-O'Driscoll syndrome and X-linked reticulate pigmentary disorder. Orthologous to human POLA1 (DNA polymerase alpha 1, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See POL1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (430087..434493)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 2-isopropylmalate synthase LEU4 Neighboring gene Met4p Neighboring gene Avt4p Neighboring gene Mic27p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in RNA-templated DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lagging strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in leading strand elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in premeiotic DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
DNA-directed DNA polymerase alpha catalytic subunit POL1
NP_014297.3
  • Catalytic subunit of the DNA polymerase I alpha-primase complex; required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    430087..434493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182940.3NP_014297.3  TPA: DNA-directed DNA polymerase alpha catalytic subunit POL1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014297.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W177, P13382
    UniProtKB/TrEMBL
    A0A8H4BVQ7, B3LNW1, N1NWK2
    Conserved Domains (2) summary
    TIGR00592
    Location:291227
    pol2; DNA polymerase (pol2)
    pfam08996
    Location:12691463
    zf-DNA_Pol; DNA Polymerase alpha zinc finger