INP52 phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: INP52
Official Full Name: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52
Primary source: SGD:S000005050
Locus tag: YNL106C
See related: AllianceGenome:SGD:S000005050; FungiDB:YNL106C; VEuPathDB:YNL106C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SJL2
Summary: Enables phosphatidylinositol phosphate phosphatase activity. Involved in phosphatidylinositol dephosphorylation. Located in actin cortical patch. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1) and SYNJ2 (synaptojanin 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See INP52 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (420944..424495, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A severe motility defect of protein internalization in a codeletant of PIL1 and SJL2 indicates a functional interplay between them in endocytosis
Title: Pil1, an eisosome organizer, plays an important role in the recruitment of synaptojanins and amphiphysins to facilitate receptor-mediated endocytosis in yeast.
Sjl2 is localized to cortical actin patches, sites of endocytosis.
Title: The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis.
results suggest that Pik1p and the Sjl proteins coordinately function to regulate the dynamic phosphorylation-dephosphorylation of the polar heads of phosphoinositides, and this process appears to be important for membrane trafficking pathways
Title: Interaction of Pik1p and Sjl proteins in membrane trafficking.
Data show that Sjl2p is specifically associated with cortical actin patches which aggregate upon loss of the actin-regulating kinases Ark1p and Prk1p.
Title: Sjl2p is specifically involved in early steps of endocytosis intimately linked to actin dynamics via the Ark1p/Prk1p kinases.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables inositol-1,4,5-trisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	RCA inferred from Reviewed Computational Analysis more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3-phosphate phosphatase activity	RCA inferred from Reviewed Computational Analysis more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	RCA inferred from Reviewed Computational Analysis more info
enables phosphatidylinositol-4-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphatidylinositol dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
located_in actin cortical patch	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in mating projection tip	HDA more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

NP_014293.1

EC 3.1.3.36

Polyphosphatidylinositol phosphatase; dephosphorylates a number of phosphatidylinositol phosphates (PtdInsPs, PIPs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain; INP52 has a paralog, INP53, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

420944..424495 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182944.1 → NP_014293.1 phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP52

See identical proteins and their annotated locations for NP_014293.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W174, P50942

UniProtKB/TrEMBL

B3LNW4, B5VQT8, C7GKD7, C8ZGC4, N1NZE4

Conserved Domains (3) summary

COG5329
Location:1 → 628

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

COG5411
Location:564 → 1052

COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]

pfam11489
Location:978 → 1166

Aim21; Altered inheritance of mitochondria protein 21