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RPC19 DNA-directed RNA polymerase core subunit RPC19 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855609, updated on 11-Jun-2025
Official Symbol
RPC19
Official Full Name
DNA-directed RNA polymerase core subunit RPC19
Primary source
SGD:S000005057
Locus tag
YNL113W
See related
AllianceGenome:SGD:S000005057; FungiDB:YNL113W; VEuPathDB:YNL113W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2 and leukodystrophy. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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See RPC19 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (412771..413199)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA2 Neighboring gene uncharacterized protein Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene Cyb5p

Genomic Sequence:
NC_001146.8
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
PubMed 
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
DNA-directed RNA polymerase core subunit RPC19
NP_014286.1
  • RNA polymerase subunit AC19; common to RNA polymerases I and III

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    412771..413199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182951.1NP_014286.1  TPA: DNA-directed RNA polymerase core subunit RPC19 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014286.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W168, P28000
    UniProtKB/TrEMBL
    A6ZRW9, B3LNX1, C7GKD1, C8ZGB7, G2WLZ3, N1NWJ5
    Conserved Domains (1) summary
    cd07029
    Location:52135
    RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III