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RPC19 DNA-directed RNA polymerase core subunit RPC19 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855609, updated on 11-Jun-2025
Official Symbol
RPC19
Official Full Name
DNA-directed RNA polymerase core subunit RPC19
Primary source
SGD:S000005057
Locus tag
YNL113W
See related
AllianceGenome:SGD:S000005057; FungiDB:YNL113W; VEuPathDB:YNL113W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to DNA-directed RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Part of RNA polymerase I complex and RNA polymerase III complex. Used to study Treacher Collins syndrome 2 and leukodystrophy. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Orthologous to human POLR1D (RNA polymerase I and III subunit D). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
all
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See RPC19 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (412771..413199)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating protein DMA2 Neighboring gene uncharacterized protein Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene Cyb5p

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. RPC19, the gene for a subunit common to yeast RNA polymerases A (I) and C (III). Dequard-Chablat M, et al. J Biol Chem, 1991 Aug 15. PMID 1869554
  2. Reconstitution of yeast and Arabidopsis RNA polymerase alpha-like subunit heterodimers. Larkin RM, et al. J Biol Chem, 1997 May 9. PMID 9139743
  3. Yeast RNA polymerase II subunit RPB11 is related to a subunit shared by RNA polymerase I and III. Woychik NA, et al. Gene Expr, 1993. PMID 8508029, Free PMC Article
  4. Treacher Collins syndrome mutations in Saccharomyces cerevisiae destabilize RNA polymerase I and III complex integrity. Walker-Kopp N, et al. Hum Mol Genet, 2017 Nov 1. PMID 28973381, Free PMC Article
  5. Rpc19 and Rpc40, two alpha-like subunits shared by nuclear RNA polymerases I and III, are interchangeable between the fission and budding yeasts. Shpakovski GV, et al. Curr Genet, 1999 Oct. PMID 10541858

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA-directed RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA-directed RNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase I IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription elongation by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase I complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RNA polymerase III complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
DNA-directed RNA polymerase core subunit RPC19
NP_014286.1
  • RNA polymerase subunit AC19; common to RNA polymerases I and III

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    412771..413199
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182951.1 → NP_014286.1  TPA: DNA-directed RNA polymerase core subunit RPC19 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014286.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W168, P28000
    UniProtKB/TrEMBL
    A6ZRW9, B3LNX1, C7GKD1, C8ZGB7, G2WLZ3, N1NWJ5
    Conserved Domains (1) summary
    cd07029
    Location:52 → 135
    RNAP_I_III_AC19; AC19 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28000.1

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