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TEP1 putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855595, updated on 9-Jun-2025
Official Symbol
TEP1
Official Full Name
putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
Primary source
SGD:S000005072
Locus tag
YNL128W
See related
AllianceGenome:SGD:S000005072; FungiDB:YNL128W; VEuPathDB:YNL128W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein tyrosine phosphatase activity. Involved in ascospore wall assembly. Located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
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See TEP1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (382359..383663)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Dgr1p Neighboring gene ribosylnicotinamide kinase Neighboring gene Far11p Neighboring gene Spc98p

Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Assessment of PTEN tumor suppressor activity in nonmammalian models: the year of the yeast. Cid VJ, et al. Oncogene, 2008 Sep 18. PMID 18794878
  2. TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation. Heymont J, et al. Proc Natl Acad Sci U S A, 2000 Nov 7. PMID 11070083, Free PMC Article
  3. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. Mitra P, et al. J Cell Biol, 2004 Jul 19. PMID 15249580, Free PMC Article
  4. Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast. Rodríguez-Escudero I, et al. Biochem J, 2005 Sep 1. PMID 15913452, Free PMC Article
  5. Identification of putative negative regulators of yeast signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways. Sacristán-Reviriego A, et al. Fungal Genet Biol, 2015 Apr. PMID 25736922

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase
NP_014271.3
  • PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    382359..383663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182966.4 → NP_014271.3  TPA: putative phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014271.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W155, P53916
    UniProtKB/TrEMBL
    A6ZRV6, B3LNY4, C7GKB8, C8ZGA3, N1P4B5
    Conserved Domains (1) summary
    cd14497
    Location:43 → 251
    PTP_PTEN-like; protein tyrosine phosphatase-like domain of phosphatase and tensin homolog and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53916.1

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