IPI3 chromatin-binding/pre-rRNA-processing protein IPI3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: IPI3
Official Full Name: chromatin-binding/pre-rRNA-processing protein IPI3
Primary source: SGD:S000005126
Locus tag: YNL182C
See related: AllianceGenome:SGD:S000005126; FungiDB:YNL182C; VEuPathDB:YNL182C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables chromatin binding activity. Involved in pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-templated DNA replication initiation; and ribosome biogenesis. Located in nucleoplasm. Part of nuclear pre-replicative complex and rixosome complex. Orthologous to human WDR18 (WD repeat domain 18). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
: Try the new Gene page
Try the new Transcripts and proteins table

Genomic context

Go to the top of the page Help

See IPI3 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (295960..297627, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified the Rix1 complex members (Ipi1p-Ipi2p/Rix1-Ipi3p) as pre-replicative complex components and critical determinants of replication licensing and replication-initiation frequency
Title: The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-replicative complex assembly involved in nuclear cell cycle DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated DNA replication initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of nuclear pre-replicative complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pre-replicative complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of rixosome complex	IBA Inferred from Biological aspect of Ancestor more info
part_of rixosome complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: chromatin-binding/pre-rRNA-processing protein IPI3

NP_014217.1

Component of the Rix1 complex and pre-replicative complexes (pre-RCs); required for processing of ITS2 sequences from 35S pre-rRNA; component of the pre-60S ribosomal particle with the dynein-related AAA-type ATPase Mdn1p; required for pre-RC formation and maintenance during DNA replication licensing; highly conserved protein which contains several WD40 motifs; IPI3 is an essential gene; other members include Rix1p, Ipi1p, and Ipi3p

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

295960..297627 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183020.1 → NP_014217.1 chromatin-binding/pre-rRNA-processing protein IPI3

See identical proteins and their annotated locations for NP_014217.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W104, P53877

UniProtKB/TrEMBL

B3LP32, B5VQM6, C7GTF5, C8ZG47, N1NXB1

Conserved Domains (2) summary

sd00039
Location:143 → 187

7WD40; WD40 repeat [structural motif]

cl29593
Location:108 → 226

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...