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NPR1 serine/threonine protein kinase NPR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855538, updated on 5-Jun-2017
Gene symbol
NPR1
Gene description
serine/threonine protein kinase NPR1
Primary source
SGD:S000005127
Locus tag
YNL183C
Gene type
protein coding
RNA name
serine/threonine protein kinase NPR1
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288c)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
See NPR1 in Map Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (293137..295509, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP10 Neighboring gene mitochondrial 54S ribosomal protein YmL19 Neighboring gene hypothetical protein Neighboring gene chromatin-binding/pre-rRNA-processing protein IPI3 Neighboring gene putative oxidoreductase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of nitrogen utilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of sphingolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Names
serine/threonine protein kinase NPR1
NP_014216.1
  • Protein kinase; stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex; NPR1 has a paralog, PRR2, that arose from the whole genome duplication

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    293137..295509 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183021.1NP_014216.1  TPA: serine/threonine protein kinase NPR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014216.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P22211
    Conserved Domains (2) summary
    smart00220
    Location:451742
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:451742
    PKc_like; Protein Kinases, catalytic domain
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