CHS1 chitin synthase CHS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: CHS1
Official Full Name: chitin synthase CHS1
Primary source: SGD:S000005136
Locus tag: YNL192W
See related: AllianceGenome:SGD:S000005136; FungiDB:YNL192W; VEuPathDB:YNL192W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: USA4
Summary: Enables chitin synthase activity. Involved in septum digestion after cytokinesis. Located in chitosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Genomic context

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See CHS1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (276502..279897)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chitin synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitin synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables chitin synthase activity	IEA Inferred from Electronic Annotation more info
enables chitin synthase activity	RCA inferred from Reviewed Computational Analysis more info
enables hexosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chitin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin biosynthetic process	RCA inferred from Reviewed Computational Analysis more info
involved_in septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell periphery	HDA more info	PubMed
is_active_in cell periphery	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell septum	IBA Inferred from Biological aspect of Ancestor more info
located_in chitosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	RCA inferred from Reviewed Computational Analysis more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitin synthase CHS1

NP_014207.2

EC 2.4.1.16

Chitin synthase I; requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

276502..279897

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183030.2 → NP_014207.2 chitin synthase CHS1

See identical proteins and their annotated locations for NP_014207.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0Z5, P08004

UniProtKB/TrEMBL

A6ZRP5, B3LP41, B5VQL8, C7GTG4, N1NXA4

Conserved Domains (3) summary

COG1215
Location:553 → 882

BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]

pfam01644
Location:454 → 619

Chitin_synth_1; Chitin synthase

pfam08407
Location:377 → 453

Chitin_synth_1N; Chitin synthase N-terminal