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SLZ1 Slz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855525, updated on 8-Mar-2025

Summary

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Official Symbol
SLZ1
Official Full Name
Slz1p
Primary source
SGD:S000005140
Locus tag
YNL196C
See related
AllianceGenome:SGD:S000005140; FungiDB:YNL196C; VEuPathDB:YNL196C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in meiotic cell cycle and negative regulation of pseudohyphal growth. Part of RNA N6-methyladenosine methyltransferase complex. [provided by Alliance of Genome Resources, Mar 2025]
Orthologs
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Genomic context

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See SLZ1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (270275..271171, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Gcr2p Neighboring gene mRNA-binding protein WHI3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. RNA methylation by the MIS complex regulates a cell fate decision in yeast. Agarwala SD, et al. PLoS Genet, 2012. PMID 22685417, Free PMC Article
  2. Systematic analysis of sporulation phenotypes in 624 non-lethal homozygous deletion strains of Saccharomyces cerevisiae. Briza P, et al. Yeast, 2002 Mar 30. PMID 11921089
  3. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Schwartz S, et al. Cell, 2013 Dec 5. PMID 24269006, Free PMC Article
  4. The yeast RNA methylation complex consists of conserved yet reconfigured components with m6A-dependent and independent roles. Ensinck I, et al. Elife, 2023 Jul 25. PMID 37490041, Free PMC Article
  5. Kar4, the yeast homolog of METTL14, is required for mRNA m6A methylation and meiosis. Park ZM, et al. PLoS Genet, 2023 Aug. PMID 37603553, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of pseudohyphal growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA N6-methyladenosine methyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Slz1p
NP_014203.1
  • Sporulation-specific protein with a leucine zipper motif; subunit of the MIS complex which controls mRNA methylation during the induction of sporulation; homologous to human ZCH13H3, a subunit of the mammalian m6A methyltransferase complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    270275..271171 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183034.1 → NP_014203.1  TPA: Slz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014203.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Z1, P40167
    UniProtKB/TrEMBL
    A6ZRP1, B3LP44, N1NWF3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40167.1

Gene LinkOut

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